University of Kansas School of Medicine Wichita, KS
Mohamed A. Omar, MD1, David Maundu, MBChB, MSc-HCM, MSc-ID2, Rahul Shekhar, MD1, Hayder Alamily, MD3, William J.. Salyers, MD, MPH4, Nathan Tofteland, MD1, Kyle Rowe, MD1 1University of Kansas School of Medicine, Wichita, KS; 2KU School of Medicine-Wichita, Wichita, KS; 3University of Colorado Anschutz Medical Campus, Denver, CO; 4University of Kansas School of Medicine - Wichita, Wichita, KS Introduction: Pancreatic divisum (PD) is the most common congenital anomaly of the pancreatic ductal system, occurring in up to 10% of the population. While most patients with PD are asymptomatic, it has been implicated as a potential risk factor for recurrent or idiopathic pancreatitis. We sought to evaluate whether patients admitted for management of pancreatitis secondary to pancreatic divisum had disparate outcomes compared to those without Methods: We analyzed 5-year data from the National Inpatient Sample (NIS) from 2018 to 2022 to identify adult hospitalizations with a primary diagnosis of acute or chronic pancreatitis using relevant ICD-10 codes. PD was identified in the secondary diagnosis field. In-hospital mortality, length of stay (LOS), total hospital charges, and ICU utilization were outcomes of interest. Results: Among an estimated 366,053 weighted pancreatitis admissions, 0.48% had a secondary diagnosis of coexisting pancreatic divisum. Compared to non-PD cases, PD patients were younger (mean age 49.9 vs. 50.9) and had a lower prevalence of alcohol use (11.8% vs. 33.6%), gallstones (5.8% vs. 15.3%), and obesity (15.3% vs. 19.1%), all p < 0.001. When adjusted for confounders, PD was associated with increased LOS (+0.67 days, p < 0.001) and higher total charges (+$6,479, p = 0.004) but showed no significant difference in in-hospital mortality (aOR 0.40, p = 0.083) or ICU use (aOR 0.60, p = 0.052). Discussion: In this large cohort study, PD was found to account for a small subset of patients with pancreatitis. Although these patients experienced longer hospital stays and higher procedural costs, pancreatic divisum was not associated with poorer short-term outcomes, although there was a trend toward significance, particularly with respect to ICU use. The higher costs and extended hospital stays were likely a result of the more extensive diagnostic workups, performed to rule out other causes prior to determining PD as the primary etiology.
Disclosures: Mohamed Omar indicated no relevant financial relationships. David Maundu indicated no relevant financial relationships. Rahul Shekhar indicated no relevant financial relationships. Hayder Alamily indicated no relevant financial relationships. William Salyers indicated no relevant financial relationships. Nathan Tofteland indicated no relevant financial relationships. Kyle Rowe indicated no relevant financial relationships.
Mohamed A. Omar, MD1, David Maundu, MBChB, MSc-HCM, MSc-ID2, Rahul Shekhar, MD1, Hayder Alamily, MD3, William J.. Salyers, MD, MPH4, Nathan Tofteland, MD1, Kyle Rowe, MD1. P0002 - Impact of Pancreatic Divisum on Inpatient Outcomes in Pancreatitis: A Nationwide Analysis, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
