P0833 - Increased Risk of Gastrointestinal and Extra-Intestinal Malignancies Among Patients Diagnosed With GIST During EGD: A Multi-Center Propensity-Matched Analysis

Mohammed Aloqaily, MD¹, Omar Abureesh, MD², Ahmad Abdulraheem, MD³, Pinghsin Hsieh, MD⁴, Yilin Song, MD⁵, Zaid Al-Fakhouri, MD⁶, Ibrahim Alfarrajin, MD⁷, Abdulla Massad, MD⁸, Ahmad Alomari, MD⁹, Boniface Mensah, MBChB, MPh¹⁰, Ade Waterman, MBChB¹¹
1University of Maryland Medical Center Midtown Campus, Baltimore, MD; 2Staten Island University Hospital, Northwell Health, Staten Island, NY; 3MedStar Washington Hospital Center, Washington, DC; 4University of Maryland Medical Center midtown campus, Baltimore, MD; 5University of Maryland Medical Center, Baltimore, MD; 6Case Western Reserve University / MetroHealth, Cleveland, OH; 7Saint Agnes Medical Center, Baltimore, MD; 8University of Texas Medical Branch, Galveston, TX; 9Henry Ford Health, Detroit, MI; 10MedStar Georgetown University Hospital, Baltimore, MD; 11MedStar Georgetown University Hospital, Washington, DC

Introduction: Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms often detected incidentally during upper endoscopy. While GISTs are associated with malignant potential, their link to other cancers is not well-defined. This study examined the risk of subsequent gastrointestinal and/or extraintestinal cancers in patients diagnosed with GIST during esophagogastroduodenoscopy (EGD).

Methods: We conducted a retrospective multi-center propensity-matched analysis using TriNetX, a global database of de-identified electronic patients' health records. Adults who underwent EGD between October 2015 and October 2024 were identified. Individuals diagnosed with GIST within one year of EGD were compared to those with no GIST diagnosis. A 1:1 propensity-matched analysis was conducted for 2143 patients in each group, controlling for age, sex, race, and ethnicity. Outcomes were assessed over a 3-year period, excluding patients with prior diagnoses of outcome malignancies.

Results: Demographics were well-balanced after matching. The mean age was 65.0 ± 13.2 years in the GIST group and 64.1 ± 14.9 in the non-GIST group. Female sex accounted for 53.1% of both groups; 58.6% were White and 19.2% Black. GIST patients showed a significantly increased risk of different types of malignancies as shown in Table 1.

Discussion: Patients diagnosed with GIST during EGD have a significantly elevated risk of multiple cancers, particularly involving the stomach, small bowel, and colon. These findings highlight the need for established surveillance in patients with GIST identified during routine EGD, along with a better understanding of demographic predictors of GISTs.


Figure: Table 1. Risk of other malignancies in patients with GIST vs matched non-GIST controls


Figure: Figure 1. Forest plot showing various malignancy risks in GIST vs non-GIST groups

Disclosures:
Mohammed Aloqaily indicated no relevant financial relationships.
Omar Abureesh indicated no relevant financial relationships.
Ahmad Abdulraheem indicated no relevant financial relationships.
Pinghsin Hsieh indicated no relevant financial relationships.
Yilin Song indicated no relevant financial relationships.
Zaid Al-Fakhouri indicated no relevant financial relationships.
Ibrahim Alfarrajin indicated no relevant financial relationships.
Abdulla Massad indicated no relevant financial relationships.
Ahmad Alomari indicated no relevant financial relationships.
Boniface Mensah indicated no relevant financial relationships.
Ade Waterman indicated no relevant financial relationships.

Mohammed Aloqaily, MD¹, Omar Abureesh, MD², Ahmad Abdulraheem, MD³, Pinghsin Hsieh, MD⁴, Yilin Song, MD⁵, Zaid Al-Fakhouri, MD⁶, Ibrahim Alfarrajin, MD⁷, Abdulla Massad, MD⁸, Ahmad Alomari, MD⁹, Boniface Mensah, MBChB, MPh¹⁰, Ade Waterman, MBChB¹¹. P0833 - Increased Risk of Gastrointestinal and Extra-Intestinal Malignancies Among Patients Diagnosed With GIST During EGD: A Multi-Center Propensity-Matched Analysis, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.