John Langley, MD, MBA, Fitsum Adane, MD, Clarisse Yapp, MD, Javier Solorzano Leon, MD, Farishta Ali, MD, Maryam Hassan, MD, Sandip Paudel, MD, Ynsnardy Hurtado Leon, MD, Karuna Bista, MD, Abdi Fite, MD, Sulav Pyakurel, MD Montefiore New Rochelle, New Rochelle, NY Introduction: The association between inflammatory bowel disease and cerebrovascular events remains unclear, despite the known link between IBD and cardiovascular events. This study investigates the impact of IBD on in-hospital outcomes in patients experiencing their first cerebrovascular event. Methods: A retrospective cohort study was conducted using the U.S. HCUP NIS Database (2016-2022). The study population included patients admitted for a first-time cerebrovascular event (acute ischemic stroke, transient ischemic attack, or acute hemorrhagic stroke) with a history of IBD (Crohn’s disease or ulcerative colitis), identified by ICD-10 codes. In-hospital mortality (primary), length of stay, resource utilization, and need for interventions (secondary) were analyzed. Multivariate analysis, adjusted for confounders, was performed. Results: Between 2016 and 2022, 694,399 patients were admitted for the first time with acute hemorrhagic stroke; 1,200 (0.17%) had concurrent ulcerative colitis. UC correlated with reduced in-hospital mortality, but increased length of stay. Among 3,691,869 patients admitted for acute ischemic stroke, 7,330 (0.20%) had UC and 9,615 (0.26%) had Crohn’s disease. UC was associated with increased length of stay and hospital charges in AIS patients. CD was associated with a lower likelihood of intracranial thrombectomy. Discussion: IBD patients experiencing a first cerebrovascular event exhibit different in-hospital outcomes compared to those without IBD. While in-hospital mortality may be reduced, length of stay and hospital charges are increased, suggesting a need for enhanced screening for cerebrovascular disease in this population.
Disclosures: John Langley indicated no relevant financial relationships. Fitsum Adane indicated no relevant financial relationships. Clarisse Yapp indicated no relevant financial relationships. Javier Solorzano Leon indicated no relevant financial relationships. Farishta Ali indicated no relevant financial relationships. Maryam Hassan indicated no relevant financial relationships. Sandip Paudel indicated no relevant financial relationships. Ynsnardy Hurtado Leon indicated no relevant financial relationships. Karuna Bista indicated no relevant financial relationships. Abdi Fite indicated no relevant financial relationships. Sulav Pyakurel indicated no relevant financial relationships.
John Langley, MD, MBA, Fitsum Adane, MD, Clarisse Yapp, MD, Javier Solorzano Leon, MD, Farishta Ali, MD, Maryam Hassan, MD, Sandip Paudel, MD, Ynsnardy Hurtado Leon, MD, Karuna Bista, MD, Abdi Fite, MD, Sulav Pyakurel, MD. P1088 - Impact of Inflammatory Bowel Disease on In-Hospital Outcomes of First-Time Cerebrovascular Disease: A Nationwide Study (2016-2022), ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
