Rabar N.. Mudhher, MD1, Zina Agha, MD2, Razhan Madhar, MD3, Gazi B.. Zibari, MD4, Hosein Shokouh-Amiri, MD4, Veron Browne, MD5 1Berkshire Medical Center, Shreveport, LA; 2Willis-Knighton, Shreveport, LA; 3Berkshire Medical Center, Pittsfield, MA; 4Willis-Knighton health, Shreveport, LA; 5willis-knighton, Shreveport, LA Introduction: Numerous studies have established the significant impact of age on surgical outcomes. However, the effects of age on both long-term and short-term outcomes following the Whipple procedure need further investigation. This study is designed to systematically compare the outcomes of Whipple procedures performed on patients aged < 65 and those who are >65
Methods: A retrospective chart review of all patients who underwent Whipple from 2010 to 2024. The study gathered data on patient demographics, duration of hospitalization, intraoperative complications, postoperative complications, 90-day,1-year, 3-year, and 5-year mortality rates. Statistical analyses were performed using Student’s t-test and Chi-square test via JASP software. Results: Out of 238 adrenalectomies performed, 90, 37.8%, patients were below the age of 65, while 148, 62.16%, were above 65. There was a statistically significant difference in their Body Mass Index (BMI), with an average BMI of 29 in patients under 65 and 30 in patients over 65, yielding a p-value of 0.03. Additionally, there was a statistically significant difference in postoperative complications, with 30 (33.3%) complications in patients under 65 and 73 (49.3%) complications in those over 65, resulting in a p-value of 0.013. The reoperation rate also differed significantly between the two groups, with 4 (4.44%) reoperations in patients under 65 and 19 (12.8%) in patients over 65, and a p-value of 0.03. Finally, there was a significant difference in the 5-year mortality rate: 20 (22.2%) in the under-65 group compared to 59 (39.8%) in the over-65 group, with a p-value of 0.02. Discussion: The Whipple procedure yields lower postoperative complications, a lower reoperation rate, and a lower 5-year mortality rate in patients aged under 65 compared to those over 65.
Figure: Outcome of Whipple procedure
Disclosures: Rabar Mudhher indicated no relevant financial relationships. Zina Agha indicated no relevant financial relationships. Razhan Madhar indicated no relevant financial relationships. Gazi Zibari indicated no relevant financial relationships. Hosein Shokouh-Amiri indicated no relevant financial relationships. Veron Browne indicated no relevant financial relationships.
Rabar N.. Mudhher, MD1, Zina Agha, MD2, Razhan Madhar, MD3, Gazi B.. Zibari, MD4, Hosein Shokouh-Amiri, MD4, Veron Browne, MD5. P2216 - Impact of Age on Outcomes of Surgical Management for Pancreaticobiliary Malignancy: Implications for Gastroenterology Practice, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
