Madison Simons, PhD1, John Brown, BA2, Jack Loesch, BA2, Matthew Allemang, MD2, Andrew Grubic, DO2, Anthony Lembo, MD, FACG1, Eyad Hamza, BA3, Michael Cline, DO2 1Cleveland Clinic Foundation, Cleveland, OH; 2Cleveland Clinic, Cleveland, OH; 3Cleveland Clinic, Cleveland, MI Introduction: Food-related quality of life (FRQOL) refers to how a person’s medical condition may affect their relationship with food/eating, and includes constructs like hypervigilance around food/eating, the effects of navigating eating on mood, social isolation related to food/eating, and the experience of food as a trigger for symptoms. The aim of this study is to explore FRQOL in patients with gastroparesis and its association with symptom severity and other cognitive affective factors. Methods: We recruited adult patients diagnosed with gastroparesis via gastric scintigraphy to complete measures assessing symptom severity, GI related quality of life, hypervigilance and symptom specific anxiety, food-related quality of life, and depression/anxiety. Data were described using mean and standard deviation (SD) for normally distributed continuous variables, median and interquartile range (IQR) for non-normally distributed continuous variables, and frequency (percentage) for categorical variables. The Spearman’s rank correlation coefficient was used to assess the relationship between questionnaire scores. Analyses were performed using R software and a significance level of 0.05 was assumed for all tests. Results: The final sample included 119 adults. Median age was 43.5 years, 95.8% White, 97.2% Non-Hispanic, 88.1% Female. 32.8% of the sample have ever required nutrition support (11.8% gastric feeds, 25.2% jejunal feeds, 15.1% total parenteral nutrition). While 55.5% of the sample reported their weight has decreased since diagnosis, with the majority (68%) having lost over 22 lbs. since diagnosis, 25.2% reported their weight has increased. Patients reported a moderate level of symptom severity (Mean PAGI-SYM=54.9 (17.0)) and low FRQOL (Median FRQOL29=42.0). Hypervigilance to physical sensation (r=-0.62, p< 0.001), symptom specific anxiety (r=-0.6, p< 0.001), and gastroparesis symptom severity (r=-0.52, p< 0.001) were moderately associated with FRQOL. Health related quality of life (r=-0.3, p=0.001), depression (r=-0.31, p=0.002), and anxiety (r=-0.39, p< 0.001) were weakly associated with FRQOL. Discussion: Hypervigilance and symptom anxiety were the most closely associated with FRQOL in patients with gastroparesis, beyond symptom severity and general mental health. This suggests targeting these cognitive affective factors is likely to help improve FRQOL, as patients’ fear around food/eating is often driven by fear of the symptoms that may result from eating.
Disclosures: Madison Simons indicated no relevant financial relationships. John Brown indicated no relevant financial relationships. Jack Loesch: Eli Lilly & Co – Stock-publicly held company(excluding mutual/index funds). Matthew Allemang indicated no relevant financial relationships. Andrew Grubic indicated no relevant financial relationships. Anthony Lembo: Allurion – Stock-publicly held company(excluding mutual/index funds). Ardeylx – Consultant. Atmo – Advisory Committee/Board Member. Bristol Myer Squibb – Stock-publicly held company(excluding mutual/index funds). GSK – Consultant. Ironwood – DSMB. J&J – Stock-publicly held company(excluding mutual/index funds). Salix – Consultant. Takeda – Consultant. Vibrant – Consultant. Eyad Hamza indicated no relevant financial relationships. Michael Cline: EVOKE Pharmaceuticals – Key Opinion Leader. Kate Farms – Key Opinion Leader.
Madison Simons, PhD1, John Brown, BA2, Jack Loesch, BA2, Matthew Allemang, MD2, Andrew Grubic, DO2, Anthony Lembo, MD, FACG1, Eyad Hamza, BA3, Michael Cline, DO2. P4183 - Food-Related Quality of Life Is Associated With Symptom Anxiety in Gastroparesis, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
