Hafsa Shahid, MD1, Samreen Zafar, MD2, Fatima Sial, MBBS3, Tehreem Asghar, 4, Saad Ashraf, 5, Qasim Bashir, MBBS6, Rabia Shahid, MBBS7, Usman Bin Hameed, MD8, Ammad Javaid. Chaudhary, MD9, Syed-Mohammed Jafri, MD9 1Brigham and Women's Hospital, Boston, MA; 2Lake Huron Medical Center, Port Huron, MI; 3King Edward Medical University, Lahore, Punjab, Pakistan; 4Akhtar Saeed Medical & Dental College, Lahore, Lahore, Punjab, Pakistan; 5Department of Medicine, Dow Medical College, Dow University of Health Sciences,, Karachi, Sindh, Pakistan; 6NISHTAR MEDICAL COLLEGE, MULTAN, PAKISTAN, Haroonabad, Punjab, Pakistan; 7Faisalabad Medical University, Pakistan, Lahore, Punjab, Pakistan; 8Corewell Health William Beaumont University Hospital, Royal Oak, MI; 9Henry Ford Health, Detroit, MI Introduction: Gastrointestinal (GI) cancers cause significant cancer-related deaths worldwide, with liver metastases contributing heavily to mortality. This study analyzes mortality trends from 1999 to 2020. Methods: CDC WONDER mortality data (1999–2020) were retrospectively analyzed. Age-adjusted mortality rates (AAMRs) per 100,000 for liver metastasis were calculated. Trends were assessed by Annual Percent Change (APC), stratified by age, sex, race/ethnicity, and region. Results: Between 1999 and 2020, 201,843 deaths due to liver metastasis in GI neoplasm patients aged ≥25 were recorded in the U.S. JointPoint regression showed a steady decline in AAMR from 1999 to 2008 (APC: -6.3171; 95% CI: 6.85–5.89), followed by a sharp increase from 2016 to 2020 (APC: 4.85; 95% CI: 3.15–5.74). Males had higher mortality increases (APC: 4.99; 95% CI: 3.25–6.00) than females (APC: 4.37; 95% CI: 1.70–5.65). By race/ethnicity, AAMR was highest among non-Hispanic Black/African Americans (APC: 3.69; 95% CI: 2.31–5.86), followed by non-Hispanic Whites (APC: 5.43; 95% CI: 4.03–6.24), Hispanics/Latinos (APC: 5.52; 95% CI: 4.48–7.10), Asians/Pacific Islanders (APC: 7.65; 95% CI: 4.69–15.42), and American Indians/Alaskan Natives (APC: 5.63; 95% CI: 2.54–15.42). Regionally, the Midwest had the highest mortality increase (APC: 6.55; 95% CI: 3.86–8.23), followed by the West (APC: 1.59; 95% CI: 1.74–5.74), South (APC: 2.11; 95% CI: 1.47–4.53), and Northeast (APC: 9.00; 95% CI: 1.85–12.58). Non metropolitan areas showed higher mortality increases (APC: 7.19; 95% CI: 6.25–8.69) than metropolitan areas (APC: 3.85; 95% CI: 0.97–6.14). Discussion: This study highlights a marked rise in liver metastasis-related mortality among U.S. adults with GI neoplasms since 2006. It underscores the need for targeted public health efforts to address disparities and improve outcomes in underserved populations.
Figure: Figure 1. Age-adjusted mortality trends from liver metastases in gastrointestinal neoplasms stratified by geography, urbanization, sex, and race/ethnicity in U.S. adults (1999–2020)
Figure: Figure 2. Age-adjusted mortality trends from liver metastases in gastrointestinal neoplasms stratified by geography, urbanization, sex, and race/ethnicity in U.S. adults (1999–2020)
Disclosures: Hafsa Shahid indicated no relevant financial relationships. Samreen Zafar indicated no relevant financial relationships. Fatima Sial indicated no relevant financial relationships. Tehreem Asghar indicated no relevant financial relationships. Saad Ashraf indicated no relevant financial relationships. Qasim Bashir indicated no relevant financial relationships. Rabia Shahid indicated no relevant financial relationships. Usman Bin Hameed indicated no relevant financial relationships. Ammad Chaudhary indicated no relevant financial relationships. Syed-Mohammed Jafri: Abbvie – Speakers Bureau. Gilead – Speakers Bureau. Intercept – Speakers Bureau. Ironwood – Speakers Bureau. Takeda – Speakers Bureau.
Hafsa Shahid, MD1, Samreen Zafar, MD2, Fatima Sial, MBBS3, Tehreem Asghar, 4, Saad Ashraf, 5, Qasim Bashir, MBBS6, Rabia Shahid, MBBS7, Usman Bin Hameed, MD8, Ammad Javaid. Chaudhary, MD9, Syed-Mohammed Jafri, MD9. P3816 - Long Term Mortality Trends in GI Neoplasms With Liver Metastases: Insight From CDC Data ( 1999-2020), ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
