Komal Khalid, MD, MBBS, BSc1, Anas Nasir, MBBS2, Muhammad Ali, MBBS3, Khizar Hayat, MBBS, MD, BSc4, Dania Hussain, MBBS5, Nikhil Duseja, MBBS6, Saif Ur Rehman, MBBS7, Sadia Ghafur, MBBS5, Haider Imran, MBBS8 1Hameed Latif Hospital, Lahore, Punjab, Pakistan; 2Shaikh Zayed Medical College, Lahore, Punjab, Pakistan; 3Dow University of Health Sciences, Sugar Land, TX; 4Waheed Khanzada Medical Center, Lahore, Punjab, Pakistan; 5united medical and dental college, Karachi, Sindh, Pakistan; 6Karachi Medical & Dental College, Karachi, Sindh, Pakistan; 7bacha khan, Mardan, North-West Frontier, Pakistan; 8Foundation University Medical College, Islamabad, Islamabad, Pakistan Introduction: The relationship between liver disease (LD) and metabolic disorders (MD) is complex and bidirectional. Given the liver’s central role in metabolism, metabolic disorders, such as Wilson disease, hemochromatosis, alpha-1 antitrypsin deficiency, hypertriglyceridemia, hypercholesterolemia, and amyloidosis, can impair hepatic function and increase mortality. Conversely, these conditions contribute to liver injury through toxic metabolite accumulation, inflammation, and oxidative stress, further elevating mortality risk. Trend analysis stratified by demographic and geographic categorization concerning LD and MD-related mortality within the United States has not been done before. This study analyses national LD and MD-related mortality trends among adults ≥ 65 years from 1999 to 2023. Methods: The CDC WONDER Multiple-Cause-of-Death dataset (1999–2023) was used to assess mortality trends in adults ≥ 65 years using ICD-10 codes for LD (K70-K76) and MD (E70-E89). Data were stratified by year, along with demographic and geographic classifications. Age-adjusted mortality rates (AAMR) were quantified per 100,000 persons with 95% confidence intervals (95%CI). Average annual percent change (AAPC) was calculated via the Joinpoint regression model, with statistical significance defined as P < 0.05. Results: A total of 62,110 LD and MD-related deaths occurred from 1999 to 2023. Overall AAMR rose from 3.7 in 1999 to 12.0 in 2023 (AAPC: 5.1; 95%CI: 4.9 to 5.4). Men had higher average AAMR compared to women, though both sexes had similar rates of increase (AAPC men: 5.2; 95%CI: 5.0 to 5.5, AAPC women: 5.2; 95%CI: 4.9 to 5.6). Racially, Hispanic/Latinos had the highest average AAMR, while non-Hispanic Whites had the highest rate of increase (AAPC: 5.4; 95%CI: 5.1 to 5.7). Regionally, the West had the highest average AAMR and the highest rate of increase (AAPC: 5.8; 95%CI: 5.3 to 6.4). From 1999 to 2020, rural areas, in comparison to urban areas, had higher average AAMR along with higher rates of increase (AAPC: 4.9; 95%CI: 4.4 to 5.3). Discussion: LD and MD-related mortality rates among adults ≥ 65 years increased significantly from 1999 to 2023, with crucial disparities across demographic and geographical classifications. These disparities illustrate the urgency for targeted interventions and public health policy changes in high-risk populations so that mortality rates can decrease in the future.
Figure: Multiple joinpoint model
Figure: Multiple joinpoint model
Disclosures: Komal Khalid indicated no relevant financial relationships. Anas Nasir indicated no relevant financial relationships. Muhammad Ali indicated no relevant financial relationships. Khizar Hayat indicated no relevant financial relationships. Dania Hussain indicated no relevant financial relationships. Nikhil Duseja indicated no relevant financial relationships. Saif Ur Rehman indicated no relevant financial relationships. Sadia Ghafur indicated no relevant financial relationships. Haider Imran indicated no relevant financial relationships.
Komal Khalid, MD, MBBS, BSc1, Anas Nasir, MBBS2, Muhammad Ali, MBBS3, Khizar Hayat, MBBS, MD, BSc4, Dania Hussain, MBBS5, Nikhil Duseja, MBBS6, Saif Ur Rehman, MBBS7, Sadia Ghafur, MBBS5, Haider Imran, MBBS8. P3764 - Trends and Disparities in Liver Disease and Metabolic Disorders-Related Mortality in Adults ≥ 65 Years From 1999 to 2023 in the United States, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
