P5333 - Increased Risk of Post-Myocardial Infarction Complications in Patients With Inflammatory Bowel Disease: A Nationwide Inpatient Sample Study From 2016 to 2022

Omar Alkasabrah, MD¹, Abdullah Hafeez, MD¹, Ritu C. Tated, MBBS, MPH², Dhruvi Joshi, MBBS³, Siddharth Agrawal, MD¹, Sameeha Ibrahim, MD⁴, Kriti Soni, MD⁵, Hritvik Jain, MBBS⁶, Jatin Thukral, MD¹, Tanuj Sharma, MD¹
1Landmark Medical Center, Woonsocket, RI; 2New York Medical College, Valhalla, NY; 3Narendra Modi Medical College, Ahmedabad, Gujarat, India; 4Jordan University of Science and Technology, Al Ramtha, Irbid, Jordan; 5SUNY Upstate Medical University, Syracuse, NY; 6All India Institute of Medical Sciences, Jodhpur, Delhi, India

Introduction: Inflammatory bowel disease (IBD), including both ulcerative colitis (UC) and Crohn’s disease, is associated with systemic inflammation that may predispose patients to adverse cardiovascular outcomes. However, data on post-myocardial infarction (MI) complications in this population remain limited.

Methods: We conducted a retrospective cohort study using the National Inpatient Sample (NIS) database from 2016 to 2022. patients hospitalized with a primary diagnosis of acute MI were identified using ICD-10-CM codes. Patients were stratified based on the presence or absence of IBD (including both UC and Crohn’s disease). Baseline characteristics, Post-MI complications, and healthcare utilization were compared between groups. Multivariate logistic regression was used to evaluate the association between IBD and post-MI complications, adjusting for demographics, comorbidities, and hospital characteristics.

Results: A total of 1,456,940 patients were included, of whom 7,430 had a diagnosis of IBD. Compared to the non-IBD cohort, IBD patients were more likely to be female (37.8% vs. 32.8%, p< 0.0001) and White (84.6% vs. 74.3%, p< 0.0001), with lower prevalence of cardiovascular risk factors hypertension (71.9% vs. 75.0%, p< 0.0001), diabetes (27.9% vs. 34.8%, p< 0.0001), and hyperlipidemia (56.19% vs. 63.08%, p< 0.0001).

After adjustment, IBD was associated with significantly increased odds of mortality (OR 3.32, 95% CI 3.18–3.47, p< 0.0001), left ventricular rupture (OR 4.46, 95% CI 3.16–6.28, p< 0.0001), left ventricular aneurysm (OR 1.93, 95% CI 1.61–2.31, p< 0.0001), stent restenosis (OR 1.16, 95% CI 1.07–1.26, p=0.0002), and acute mitral regurgitation (OR 9.80, 95% CI 6.81–14.10, p< 0.0001). There was no statistically significant difference in the odds of pericarditis (OR 0.84, 95% CI 0.67–1.04, p=0.0995). Moreover, IBD patients had longer hospital stays (R=2.13 days, 95% CI 2.03–2.23, p< 0.0001).

Discussion: Despite having a lower burden of traditional cardiovascular risk factors, patients with IBD who suffer from MI experience significantly higher rates of life-threatening cardiac complications and increased healthcare utilization. Prospective studies are warranted to better understand the underlying mechanisms and long-term impact of IBD on post-MI outcomes.


Figure: Table 1. Baseline Demographics, Hospital Characteristics, and Comorbidities in Patients With and Without Inflammatory Bowel Disease Presenting With Myocardial Infarction


Figure: Table 2. Outcomes Following Myocardial Infarction in Patients With inflammatory bowel disease vs Without inflammatory bowel disease

Disclosures:
Omar Alkasabrah indicated no relevant financial relationships.
Abdullah Hafeez indicated no relevant financial relationships.
Ritu C. Tated indicated no relevant financial relationships.
Dhruvi Joshi indicated no relevant financial relationships.
Siddharth Agrawal indicated no relevant financial relationships.
Sameeha Ibrahim indicated no relevant financial relationships.
Kriti Soni indicated no relevant financial relationships.
Hritvik Jain indicated no relevant financial relationships.
Jatin Thukral indicated no relevant financial relationships.
Tanuj Sharma indicated no relevant financial relationships.

Omar Alkasabrah, MD¹, Abdullah Hafeez, MD¹, Ritu C. Tated, MBBS, MPH², Dhruvi Joshi, MBBS³, Siddharth Agrawal, MD¹, Sameeha Ibrahim, MD⁴, Kriti Soni, MD⁵, Hritvik Jain, MBBS⁶, Jatin Thukral, MD¹, Tanuj Sharma, MD¹. P5333 - Increased Risk of Post-Myocardial Infarction Complications in Patients With Inflammatory Bowel Disease: A Nationwide Inpatient Sample Study From 2016 to 2022, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.