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Monday Poster Session

Category: Esophagus

P2757 - Magnetic Sphincter Augmentation versus Fundoplication for Gastroesophageal Reflux Disorder: A Systematic Review and Meta-Analysis of Postoperative Outcomes

Monday, October 27, 2025
10:30 AM - 4:00 PM MT
Location: Exhibit Hall
Muhammad Usman Haider, MD1, Ishtiaq Ahmad, MD1, Mohammed Amer. Kamel, MD2, Yonatan Abbawa Zewdie, MD3, Sai Venkata Siddhartha Masetti, MD4, Mira Odeessa Pereira, MD5, Maham Afzal, MBBS6, Akash Rawat, MD7, Sahibzada Zumeran Jah, MBBS8, Prachi P. Salunke, MD9, Suhas Kataveni, MBBS10, Zainab Shaheen, 11, Abdulrahman N. Bukamal, MD12, Shahad Abu Ahmad, 13, Mirza Muhammad Hadeed Khawar, MBBS8, Ahmad Sameed Akram, MBBS14
1Geisinger Health System, Wilkes-Barre, PA; 2university, Bethlehem, Palestinian Territories; 3Addis Ababa University, College of Health Science, School of Medicine, Black Lion Specialized Hospital, Addis Ababa, Adis Abeba, Ethiopia; 4kingston Public Hospital, Aldie, VA; 5Northampton General Hospital, Northampton, England, United Kingdom; 6Shalamar Institute of Health Sciences, Montreal, PQ, Canada; 7Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India; 8Services Institute of Medical Sciences, Lahore, Punjab, Pakistan; 9Tver State Medical University, Thane, Maharashtra, India; 10Gandhi medical college, Hyderabad, Telangana, India; 11Aligarh Muslim University, Aliagrh, Uttar Pradesh, India; 12RCSI BAHRAIN, Hidd, Al Muharraq, Bahrain; 13Al-Quds University, Nazareth, HaMerkaz, Israel; 14King Edward Medical University, Shakargarh, Punjab, Pakistan

Introduction: Gastroesophageal reflux disease (GERD) is commonly treated with surgical interventions such as magnetic sphincter augmentation (MSA) or fundoplication (FP). However, comparative data on their efficacy and safety remain limited. This meta-analysis evaluates postoperative outcomes of MSA versus FP in GERD management.

Methods: A systematic literature search was conducted across PubMed, Cochrane Library, ScienceDirect, and Embase up to April 2025, identifying studies comparing MSA and FP for GERD. Pooled odds ratios (ORs) or mean differences (MDs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was assessed with the I² statistic, and statistical significance was set at p < 0.05.

Results: Twelve studies, published between 2014 and 2024, were included. No significant differences were observed in postoperative PPI use (OR: 0.70, 95% CI: 0.30–1.67, p=0.40, I²=85%) or GERD-HRQL scores (MD: 0.67, 95% CI: -0.57–1.91, p=0.29, I²=68%) between MSA and FP. MSA significantly improved the ability to belch (OR: 6.78, 95% CI: 4.49–10.22, p< 0.00001, I²=43%) and ability to vomit (OR: 5.85, 95% CI: 2.39–14.33, p=0.0001, I²=82%) compared to FP. Dysphagia rates were similar (OR: 1.12, 95% CI: 0.59–2.14, p=0.72, I²=72%). MSA significantly reduced gas bloating risk (OR: 0.43, 95% CI: 0.25–0.75, p=0.003, I²=54%).

Discussion: MSA and FP demonstrate comparable efficacy in GERD symptom control, PPI use, and dysphagia. MSA offers significant advantages in preserving the ability to belch and vomit and reducing gas bloating. Substantial heterogeneity in several outcomes warrants
cautious interpretation, and further studies are needed to optimize surgical approaches.

Disclosures:
Muhammad Usman Haider indicated no relevant financial relationships.
Ishtiaq Ahmad indicated no relevant financial relationships.
Mohammed Kamel indicated no relevant financial relationships.
Yonatan Abbawa Zewdie indicated no relevant financial relationships.
Sai Venkata Siddhartha Masetti indicated no relevant financial relationships.
Mira Odeessa Pereira indicated no relevant financial relationships.
Maham Afzal indicated no relevant financial relationships.
Akash Rawat indicated no relevant financial relationships.
Sahibzada Zumeran Jah indicated no relevant financial relationships.
Prachi P. Salunke indicated no relevant financial relationships.
Suhas Kataveni indicated no relevant financial relationships.
Zainab Shaheen indicated no relevant financial relationships.
Abdulrahman Bukamal indicated no relevant financial relationships.
Shahad Abu Ahmad indicated no relevant financial relationships.
Mirza Muhammad Hadeed Khawar indicated no relevant financial relationships.
Ahmad Sameed Akram indicated no relevant financial relationships.

Muhammad Usman Haider, MD1, Ishtiaq Ahmad, MD1, Mohammed Amer. Kamel, MD2, Yonatan Abbawa Zewdie, MD3, Sai Venkata Siddhartha Masetti, MD4, Mira Odeessa Pereira, MD5, Maham Afzal, MBBS6, Akash Rawat, MD7, Sahibzada Zumeran Jah, MBBS8, Prachi P. Salunke, MD9, Suhas Kataveni, MBBS10, Zainab Shaheen, 11, Abdulrahman N. Bukamal, MD12, Shahad Abu Ahmad, 13, Mirza Muhammad Hadeed Khawar, MBBS8, Ahmad Sameed Akram, MBBS14. P2757 - Magnetic Sphincter Augmentation versus Fundoplication for Gastroesophageal Reflux Disorder: A Systematic Review and Meta-Analysis of Postoperative Outcomes, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.