P2222 - Mortality Trends and Health Disparities in Gallbladder, Biliary Tract, and Pancreatic Disorders: A US National Study (1999-2020)

Umar Farooque, MBBS¹, Meer Murtaza, MBBS², Fnu Arti, MD³, Nikil Kumar, ⁴, Iffat ambreen Magsi, ⁵, Muddassir Khalid, MBBS⁶, Hafsa Ajmal, MBBS⁷, Nazeer Ahmed, ⁸, Aasma Shaukat, MD, MPH, FACG⁹
1Health Education England, East of England, United Kingdom, Luton, England, United Kingdom; 2Liaquat University of Medical and Health Science, Shahpur Chakar, Sindh, Pakistan; 3Saint Francis Medical Center, Monroe, LA; 4Liaquat University of Medical and Health Science, Hyderabad, Sindh, Pakistan; 5shaheed muhtarma benazir bhutto medical college liyari,karachi., Karachi, Sindh, Pakistan; 6Nishtar Medical University, Chichawatni, Punjab, Pakistan; 7King Edward Medical University, Lahore, Punjab, Pakistan; 8Karachi Medical and Dental College karachi, Karachi, Sindh, Pakistan; 9NYU Grossman School of Medicine, Division of Gastroenterology and Hepatology, New York, NY

Introduction: Disorders of the gallbladder, biliary tract, and pancreas (GBP), including cholelithiasis, cholecystitis, cholangitis, pancreatitis, and pancreatic cysts, are significant contributors to gastrointestinal mortality in the United States. Despite advances in diagnosis and treatment, mortality remains high, and disparities persist across demographic and geographic lines. This study aimed to evaluate long-term mortality trends from GBP disorders in the U.S. adult population from 1999 to 2020.

Methods: Data were extracted from CDC WONDER (1999–2020) for adults ≥25 years with deaths linked to GBP disorders (ICD-10: K80–K86). Age-adjusted mortality rates (AAMRs) per 100,000 were standardized to the 2000 U.S. population. Joinpoint regression estimated Annual Percentage Change (APC), Average Annual Percentage Change (AAPC), and 95% confidence intervals (CIs). Subgroup analyses included sex, race/ethnicity, region, urban-rural status, place of death, and state.

Results: From 1999–2020, 359,358 U.S. deaths were due to GBP disorders. The age-adjusted mortality rate (AAMR) declined from 8.79 (1999) to 8.15 (2020), with stable rates (1999–2002), declines (2002–2013), and an increase post-2018 (APC: 6.55; 95% CI: 4.11–9.04) (Figure 1). Males had higher AAMR than females (9.10 vs 6.29) (Figure 1). AAMR rose with age: 25–44 (1.35), 45–64 (4.94), and 65–85+ (26.97), with sharpest recent rise in ages 25–44 (APC: 21.48). By race, AAMR was highest in American Indian/Alaska Natives (11.21), followed by Black (9.46), White (7.43), Hispanic (7.17), and Asian/Pacific Islander (5.69) (Figure 2). Rural mortality (8.93) exceeded urban (7.31) (Figure 2). Regionally, the West had the highest AAMR (8.03), Northeast the lowest (6.71). Most deaths (67.97%) occurred in medical facilities.

Discussion: Although mortality due to GBP disorders declined through the early 2000s, a resurgence in deaths occurred from 2018 to 2020, particularly among males, Black individuals, the rural population, and residents of states like West Virginia and New Mexico, highlighting growing disparities. These findings underscore the need for targeted public health strategies focused on early detection, risk factor modification, and equitable healthcare access to reduce preventable mortality and mitigate widening health inequities.

ChatGPT (OpenAI) was used for language clarity and grammar refinement. All scientific content, data, and analysis are original and solely by the authors.


Figure: Figure 1. AAMR overall (top) and across sex (bottom) associated with disorders of the gallbladder, biliary tract, and pancreas in the US from 1999 to 2020.


Figure: Figure 2. AAMR across race (top) and urbanization (bottom) associated with disorders of the gallbladder, biliary tract, and pancreas in the US from 1999 to 2020.

Disclosures:
Umar Farooque indicated no relevant financial relationships.
Meer Murtaza indicated no relevant financial relationships.
Fnu Arti indicated no relevant financial relationships.
Nikil Kumar indicated no relevant financial relationships.
Iffat ambreen Magsi indicated no relevant financial relationships.
Muddassir Khalid indicated no relevant financial relationships.
Hafsa Ajmal indicated no relevant financial relationships.
Nazeer Ahmed indicated no relevant financial relationships.
Aasma Shaukat: Freenome inc – Consultant.

Umar Farooque, MBBS¹, Meer Murtaza, MBBS², Fnu Arti, MD³, Nikil Kumar, ⁴, Iffat ambreen Magsi, ⁵, Muddassir Khalid, MBBS⁶, Hafsa Ajmal, MBBS⁷, Nazeer Ahmed, ⁸, Aasma Shaukat, MD, MPH, FACG⁹. P2222 - Mortality Trends and Health Disparities in Gallbladder, Biliary Tract, and Pancreatic Disorders: A US National Study (1999-2020), ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.