P2213 - 24-Year Trends in Gallbladder Carcinoma Deaths in the United States: Insights From the CDC WONDER Database

Ahmed Shukri, MD¹, Minhail Malik, MD², Mohamed Shoukrie, BS³, Muhammad Ali Tariq, MD⁴
1Texas Tech University Health Sciences Center, Lubbock, TX; 2Dow University of Health Sciences, Lubbock, TX; 3West Texas Digestive disease center, Lubbock, TX; 4Dow University of Health Sciences, Karachi, Islamabad, Pakistan

Introduction: Although relatively rare, gallbladder cancer, characterized by its aggressive nature and poor prognosis, accounts for over 50% of all malignancies in the biliary tract. Contemporary mortality trends due to gallbladder cancer (GBC) are largely unknown. The study aims to examine the temporal trends of GBC-related deaths among older adults in the United States from 1999 to 2023.

Methods: We utilized the Centers for Disease Control (CDC WONDER) database to access the national mortality records from 1999 to 2023. The demographic and mortality data were obtained for the United States adult population aged ≥ 25 years. Gallbladder cancer-related deaths (ICD-10: C23) as a contributing or underlying cause of death were identified. Age-adjusted mortality rates (AAMR) per 100,000 population were calculated by standardizing deaths to the 2000 US Standard population. Using the Joinpoint regression program, we calculated the average annual percentage change (AAPC), along with 95% confidence intervals, to analyze trends.

Results: 55,383 deaths associated with GBC occurred between 1999 and 2023. Overall, there is a declining trend in GBC mortality, the total AAMR decreased from 1.30 in 1999 to 0.85 in 2023 (AAPC -1.4, Figure 1). The AAMR remained consistently higher in females (overall AAMR: 0.74) than in males (overall AAMR: 1.2) throughout the study period, and the AAMRs for both decreased (APC men: -1.2%; women: -1.4%; Figure 1). When stratified by race, AAMR was highest among the Hispanic population (1.57), followed by Non-Hispanic (NH) Blacks (1.39) and NH Asians (1.16). In brief, the AAMR has decreased for all races except for NH blacks (Figure 2). The Hispanic population has experienced the greatest decline in AAMR during the study duration (AAPC: -1.4%). Adults aged >65 years exhibited higher AAMRs (3.73) compared to adults aged 25-64 Years (0.57). Geographically, metropolitan areas (1.10) exhibited higher AAMRs compared to non-metropolitan areas (0.96), with Northeast region showing highest mortality.

Discussion: Over the past two decades, there has been a consistent decline in mortality rates associated with gallbladder carcinoma in the United States. Specific demographic groups, including individuals in metropolitan areas, males, Hispanics, Blacks and Asians populations have experienced disparities. These disparities necessitate further investigation and targeted solutions for these subgroups.


Figure: Figure 1


Figure: Figure 2

Disclosures:
Ahmed Shukri indicated no relevant financial relationships.
Minhail Malik indicated no relevant financial relationships.
Mohamed Shoukrie indicated no relevant financial relationships.
Muhammad Ali Tariq indicated no relevant financial relationships.

Ahmed Shukri, MD¹, Minhail Malik, MD², Mohamed Shoukrie, BS³, Muhammad Ali Tariq, MD⁴. P2213 - 24-Year Trends in Gallbladder Carcinoma Deaths in the United States: Insights From the CDC WONDER Database, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.