Metropolitan University College of Medicine Torrance, CA
Dhruv Gandhi, MD1, Siddidha Bokka, MD2, Wajdan Ahmad, MD3, Ayesha Cheema, MBBS3, Hareesha Rishab Bharadwaj, 4, Hassam Ali, MD5, Saqr Alsakarneh, MD, MSc6, Omar Al Ta’ani, MD7, Fariha Hasan, MD8, Sneh Sonaiya, MD, MPH, MBA9, Syed Hasham Ali, MD10, Dushyant S. Dahiya, MD11, Balamrit Singh Sokhal, MD12, Farhan Gohar, MD13 1St Francis Medical Center, Monroe, LA, Mumbai, Maharashtra, India; 2Metropolitan University College of Medicine, Torrance, CA; 3Al-Tibri Medical College, Karachi, Sindh, Pakistan; 4The University of Manchester, Manchester, England, United Kingdom; 5East Carolina University/Brody School of Medicine, Greenville, NC; 6Mayo Clinic, Rochester, MN; 7Department of Internal Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania, USA, Pittsburgh, PA; 8Cooper University Hospital, Camden, NJ; 9Kirk Kerkorian School of Medicine at the University of Nevada Las Vegas, Las Vegas, NV; 10Dow University of Health Sciences, Karachi, Punjab, Pakistan; 11University of Kansas School of Medicine, Kansas City, KS; 12Royal Stroke University Hospital, Staffordshire, England, United Kingdom; 13Royal Stoke University Hospital, Staffordshire, England, United Kingdom Introduction: To determine trends and disparities in hepatitis-B mortality in American adults older than 25 years between 1999-2020. Methods: Retrospective analysis of Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database was performed. For hepatitis-B, International Classification of Diseases-10 codes B16.0-16.2, B16.9, B17.0, B18.0, B18.1 were employed. Age-adjusted mortality rates(AAMR) and crude death rates(CDR) per 100,000 persons were determined. Average annual percentage change(AAPC) was determined using Joinpoint regression. Temporal trends were analyzed in sex, race, geographical distribution and patient age-related mortality. Results: A total of 38,845 deaths from hepatitis-B were reported. AAMRs declined sharply from 1.12 to 0.87 between 1999-2004(AAPC:-4.45;p< 0.001) followed by a steady decline from 0.87 to 0.69(AAPC:-1.64;p< 0.001), resulting in an overall AAMR of 0.82(AAPC:-2.31;p< 0.001). Males had disproportionately higher AAMR(1.28) as compared to females(0.41) and showed a greater decline in mortality(AAPC:-2.62;p< 0.001) than females(AAPC:-2.13;p< 0.001). Among races, NH Asian/Pacific Islanders had a disproportionately higher AAMR(4.04) followed by NH Blacks(1.45), NH American Indians/Alaskan Natives(0.9), Hispanic(0.71), and NH White(0.55). All races saw decline in AAMR, with the greatest decline seen in Hispanic(AAPC:-6.43;p< 0.001). Geographically, AAMRs were highest in West(1.17) followed by South(0.83). All census regions saw a decline in AAMR, with the greatest decline seen for Northeast(AAPC:-3.38;p< 0.001). Metropolitan areas had a higher AAMR(0.84) than nonmetropolitan areas(0.59) and saw a greater decline in AAMR(AAPC:-2.86;p< 0.001) than nonmetropolitan areas(AAPC:-0.55;p=0.059). Of the 10-year age groups, CDR was highest for 55-64 years(1.46). The age groups of 25-34, 35-44, 45-54, and 55-64 years saw declining AAMRs, with the greatest decline seen for 35-44 years(AAPC:-5.64;p< 0.001). However, 65-74, 75-84, and 85+ years saw an increase in AAMRs, with the greatest increase seen for 85+ years(AAPC:1.12;p=0.037). Discussion: We found a significant decline in hepatitis-B mortality, though persistent disparities exist. Males, NH Asian/Pacific Islanders, residents of West and metropolitan areas experienced disproportionately higher mortality rates. All demographic groups saw decline in mortality except 65-74, 75-84, and 85+ year age groups, which saw increases in mortality.
Figure: Trends based on Race
Figure: Trends based on Gender
Disclosures: Dhruv Gandhi indicated no relevant financial relationships. Siddidha Bokka indicated no relevant financial relationships. Wajdan Ahmad indicated no relevant financial relationships. Ayesha Cheema indicated no relevant financial relationships. Hareesha Rishab Bharadwaj indicated no relevant financial relationships. Hassam Ali indicated no relevant financial relationships. Saqr Alsakarneh indicated no relevant financial relationships. Omar Al Ta’ani indicated no relevant financial relationships. Fariha Hasan indicated no relevant financial relationships. Sneh Sonaiya indicated no relevant financial relationships. Syed Hasham Ali indicated no relevant financial relationships. Dushyant Dahiya indicated no relevant financial relationships. Balamrit Singh Sokhal indicated no relevant financial relationships. Farhan Gohar indicated no relevant financial relationships.
Dhruv Gandhi, MD1, Siddidha Bokka, MD2, Wajdan Ahmad, MD3, Ayesha Cheema, MBBS3, Hareesha Rishab Bharadwaj, 4, Hassam Ali, MD5, Saqr Alsakarneh, MD, MSc6, Omar Al Ta’ani, MD7, Fariha Hasan, MD8, Sneh Sonaiya, MD, MPH, MBA9, Syed Hasham Ali, MD10, Dushyant S. Dahiya, MD11, Balamrit Singh Sokhal, MD12, Farhan Gohar, MD13. P1303 - Trends and Disparities in Hepatitis B Mortality in the United States Between 1999-2020, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
