Saint Michael's Medical Center, New York Medical College Newark, NJ
Mohamed Eldesouki, MD1, Mohammad Kloub, MD2, Khaled Elfert, MBChB, MRCP3, Ahmed Ibrahim, MD4, Ahmed Salem, MD5, Mohammed Y. Youssef, MD6, Hazem Abosheaishaa, MD7, Yamini Katamreddy, MD8, Swapna Gayam, MD9 1Saint Michael's Medical Center, New York Medical College, Newark, NJ; 2New York Medical College - Saint Michael's Medical Center, Bloomfield, NJ; 3West Virginia University School of Medicine, Morgantown, WV; 4Medical University of South Carolina, Charleston, SC; 5Maimonides Medical Center, Brooklyn, NY; 6Hunt Regional Medical Center, Greenville, TX; 7Mount Sinai West, Icahn School of Medicine at Mount Sinai, Queens, NY; 8New York Medical College - Saint Micheal’s Medical Center, Newark, NJ; 9GI and Hepatology - West Virginia University, West Virginia, VA Introduction: Infectious gastroenteritis (IGE) has been associated with the developmentment of irritable bowel syndrome (IBS) and other functional dyspepsia (FD). However, long-term outcomes remain inadequately characterized. We aimed to examine the long-term risk of IBS and FD following IGE using a large, multicenter electronic database. Methods: A retrospective cohort study using the TriNetX US Collaborative Network. We included adult patients aged 18 years and older from Jan 2000 to Dec 2014, who developed IGE. P</span>atients with anxiety, depression, lactose intolerance, inflammatory bowel disease, gallbladder disease, anorexia nervosa, and bulimia nervosa were excluded. Adults diagnosed with IGE (cohort 1) were matched 1:1 with controls without IGE (cohort 2) using propensity score matching for demographics and comorbidities(Table 1). Study outcomes were assessed at 1, 5, and 10 years. Primary outcomes included the incidence of IBS, and functional dyspepsia. Secondary outcomes were diarrhea, constipation, bloating, nausea and/or vomiting. Outcomes were expressed in adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were calculated. Results: After PSM, each cohort included 132,340 patients. As shown in Table 2, Patients in cohort 1 had a significantly increased risk of developing IBS and FD compared to cohort 2 at 1, 5, and 10 years after the infection. At 1-year follow-up, The incidence of IBS was higher in cohort 1 (aOR 1.18; 95% CI: 1.03–1.35; p = 0.015), as was the incidence of FD (aOR 1.49; 95% CI: 1.24–1.78; p < 0.001). At 5 years, the risk remained elevated for both IBS (aOR 1.12; 95% CI: 1.03–1.21; p = 0.008) and functional dyspepsia (aOR 1.52; 95% CI: 1.38–1.68; p < 0.001). This increased risk persisted at 10 years for both IBS (aOR 1.24; 95% CI: 1.16–1.33; p < 0.001), and FD (aOR 1.57; 95% CI: 1.45–1.71; p < 0.001). Discussion: Infectious gastroenteritis is associated with an increased risk of irritable bowel syndrome and other functional dyspepsia at 1, 5, and 10 years after the infection. These results highlight the importance of carefully monitoring patients with a history of infectious gastroenteritis over time, especially if they continue to experience digestive symptoms.
Figure: Table 1: Baseline characteristics of the patients before and after 1:1 propensity score matching
Figure: Table 2: Comparison of the outcomes between infectious enteritis and controls groups at 1,5, and 10 years
Disclosures: Mohamed Eldesouki indicated no relevant financial relationships. Mohammad Kloub indicated no relevant financial relationships. Khaled Elfert indicated no relevant financial relationships. Ahmed Ibrahim indicated no relevant financial relationships. Ahmed Salem indicated no relevant financial relationships. Mohammed Y. Youssef indicated no relevant financial relationships. Hazem Abosheaishaa indicated no relevant financial relationships. Yamini Katamreddy indicated no relevant financial relationships. Swapna Gayam indicated no relevant financial relationships.
Mohamed Eldesouki, MD1, Mohammad Kloub, MD2, Khaled Elfert, MBChB, MRCP3, Ahmed Ibrahim, MD4, Ahmed Salem, MD5, Mohammed Y. Youssef, MD6, Hazem Abosheaishaa, MD7, Yamini Katamreddy, MD8, Swapna Gayam, MD9. P0788 - Long-Term Risk of Irritable Bowel Syndrome and Functional Dyspepsia Following Infectious Gastroenteritis: A 10-Year Retrospective Cohort Study, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
