Muhammad Ismail, MD1, David LeRoy, DO2, Mohamad Besher Adi, MD3, Raquel Rudy, DO, MS2, Ermal Hasalliu, DO4, Niketh Chopra, DO5, Ian Dominguez, DO2, Amaani Desai, DO2, Elaine Ognjanovski, DO6, Fady Banno, MD7, Nafea Zayouna, MD8, Leonid Shamban, DO9, Mohammed Barawi, MD4 1Henry Ford Health, Cedar Rapids, IA; 2Henry Ford Warren Hospital, Warren, MI; 3Ascension St. John Hospital, St. Clair Shores, MI; 4Henry Ford Health, Detroit, MI; 5Henry Ford Warren, Warren, MI; 6Henry Ford Health, Warren, MI; 7Carewell Health William Beaumont Hospital, Royal Oak, MI; 8Henry Ford, Warren, Michigan, Clinton Township, MI; 9Ascension St. John Hospital, Macomb, MI Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths both in the United States and globally. A comprehensive state-specific trend and disparity analysis of CRC incidence can aid in optimizing screening and prevention efforts, and assist researchers in investigating cultural disparities and their underlying causes. This study aims to explore and compare temporal trends in CRC incidence across different demographic strata in Michigan (MI) and the United States. Methods: CRC incidence data from 1999 to 2021 were extracted from the United States Cancer Statistics – Incidence dataset via the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) Online Database. Age-adjusted Rates (AARs) and Crude Rates per 100,000 persons were extracted for a comprehensive analysis. Average Annual Percent Change (AAPC) was calculated via the JoinPoint software. Results: From 1999 to 2021, the overall CRC incidence rates in Michigan closely paralleled national trends, with both showing an AAR of 42.2. Significant declines in CRC incidence were observed in both regions (AAPC: MI; -2.71 CI: (-3.10 to -2.38)), (AAPC: US; -2.30 CI: (-2.52 to -2.05)). Men had greater rates than women with similar incidence across both regions (MI AAR: males 48.2, females 37.2; US AAR: males 48.9, females 36.7). Non-Hispanic (NH) Black/African American individuals had the highest incidence among racial/ethnic groups, Michigan rates were slightly higher (AAR: 52.8) than nationally (AAR: 49.4). Asian/Pacific Islanders had the lowest rates, with Michigan showing relatively lower rates (AAR: 27.4) compared to national rates (AAR: 32.3). Adults aged 85+ had the highest incidence rates among all age groups in both Michigan and the US (MI Crude Rate: 309.1, US Crude Rate: 315.4). Notably, CRC incidence in younger/middle-aged adults (age group 40-54 in MI and 25-54 in the US) increased over the last two decades, while incidence in adults aged 55+ declined in both regions. Discussion: CRC incidence trends in Michigan mirrored national patterns over the last two decades, with significant declines overall, especially in older adults. Men consistently had higher rates than women, and NH Black/African Americans experienced higher incidence rate among all racial/ethnic groups, with slightly more pronounced Michigan rates. While overall CRC AARs declined significantly, the incidence among younger/middle-aged adults rose (age groups 25-54 in US overall and 40-54 in MI).
Figure: Comparative Analysis of Age-Adjusted Colorectal Cancer Incidence Rates (per 100,000) in Michigan and the United States (1999-2021).
Figure: Overall Age-adjusted Colorectal Cancer Incidence rates per 100,000 persons in the United States and Michigan by racial/ethnic groups from 1999 to 2021.
Disclosures: Muhammad Ismail indicated no relevant financial relationships. David LeRoy indicated no relevant financial relationships. Mohamad Besher Adi indicated no relevant financial relationships. Raquel Rudy indicated no relevant financial relationships. Ermal Hasalliu indicated no relevant financial relationships. Niketh Chopra indicated no relevant financial relationships. Ian Dominguez indicated no relevant financial relationships. Amaani Desai indicated no relevant financial relationships. Elaine Ognjanovski indicated no relevant financial relationships. Fady Banno indicated no relevant financial relationships. Nafea Zayouna indicated no relevant financial relationships. Leonid Shamban indicated no relevant financial relationships. Mohammed Barawi indicated no relevant financial relationships.
Muhammad Ismail, MD1, David LeRoy, DO2, Mohamad Besher Adi, MD3, Raquel Rudy, DO, MS2, Ermal Hasalliu, DO4, Niketh Chopra, DO5, Ian Dominguez, DO2, Amaani Desai, DO2, Elaine Ognjanovski, DO6, Fady Banno, MD7, Nafea Zayouna, MD8, Leonid Shamban, DO9, Mohammed Barawi, MD4. P0514 - Trends in Colorectal Cancer Incidence: A Comparative Analysis of Michigan and the United States (1999-2021), ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
