P0511 - Trends in Early-Onset Colorectal Cancer Mortality by Sex in the United States, 2018–2023: A CDC WONDER Analysis

Yousuf Hassan Syed, MD¹, Rohan Raj, MBBS², Pranay T. Vaghela, MBBS³, Nandini Hemant. Patel, MBBS⁴, Jyoti Yadav, MBBS⁵, Jithin Kolli, MBBS⁶, Hari Priya Nistala, MBBS⁷, Rupak Desai, MBBS⁸
1Team Health, Las Vegas, NV; 2Memorial Hospital at Gulfport, Gulfport, MS; 3The Maharaja Sayajirao University of Baroda, Navsari, Gujarat, India; 4Pramukhswami Medical College, Gujarat, India, Anand, Gujarat, India; 5JSS Medical college, Mysore, Karnataka, India; 6JSS MEDICAL COLLEGE, Andra Pradesh, Andhra Pradesh, India; 7Maharajah's Institute of Medical Sciences, Leander, TX; 8Independent Outcomes Researcher, Atlanta, GA

Introduction: Colorectal cancer (CRC) mortality among younger adults is an emerging public health concern. This study evaluates trends in CRC-related mortality from 2018 to 2023 among individuals aged 25–54 years, stratified by sex, using CDC WONDER data.

Methods: We analyzed U.S. Multiple Cause of Death data for CRC (ICD-10: C18.0–C20) in adults aged 25–54. Crude and age-adjusted mortality rates (AAMRs) per 100,000 population were calculated, along with 95% confidence intervals (CIs), separately for males and females. Temporal trends in AAMRs were assessed using the Joinpoint log-linear regression model to compute the Annual Percent Change (APC)

Results: A total of 39,951 CRC-related deaths were identified (16,879 females and 23,072 males). The average AAMR was 4.4 (95% CI: 4.3–4.5) for females and 6.1 (95% CI: 6.0–6.2) for males. Female AAMRs rose modestly from 4.3 in 2018 to 4.6 in 2023, while male AAMRs increased from 6.0 to 6.3 over the same period. Males consistently exhibited higher mortality across all years. Joinpoint regression revealed a positive APC in AAMRs for both sexes, reflecting a gradual upward trend in early-onset CRC mortality.

Discussion: From 2018 to 2023, early-onset CRC mortality in the U.S. demonstrated a rising trend, with males experiencing consistently higher AAMRs than females. These findings highlight the urgent need for sex-specific strategies in screening, prevention, and public health interventions targeting young adults.


Figure: Trends in age-adjusted Colorectal cancer mortality rates among US adults aged 25-54 by sex, 2018-2023. Solid lines show actual rates. The dashed lines represent Log-linear regression trend lines used for Calculating Annual Percentage (APC)


Figure: Age-adjusted Colorectal cancer mortality rates among US adults aged 25-54 by sex, 2018- 2023

Disclosures:
Yousuf Hassan Syed indicated no relevant financial relationships.
Rohan Raj indicated no relevant financial relationships.
Pranay Vaghela indicated no relevant financial relationships.
Nandini Patel indicated no relevant financial relationships.
Jyoti Yadav indicated no relevant financial relationships.
Jithin Kolli indicated no relevant financial relationships.
Hari Priya Nistala indicated no relevant financial relationships.
Rupak Desai indicated no relevant financial relationships.

Yousuf Hassan Syed, MD¹, Rohan Raj, MBBS², Pranay T. Vaghela, MBBS³, Nandini Hemant. Patel, MBBS⁴, Jyoti Yadav, MBBS⁵, Jithin Kolli, MBBS⁶, Hari Priya Nistala, MBBS⁷, Rupak Desai, MBBS⁸. P0511 - Trends in Early-Onset Colorectal Cancer Mortality by Sex in the United States, 2018–2023: A CDC WONDER Analysis, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.