P0313 - Efficacy and Safety of FOLFOXIRI Plus Cetuximab versus FOLFOXIRI Plus Bevacizumab for Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis

Ahmed Raza, ¹, Faiza Fatima, MBBS¹, Muhammad Saffi Ullah, MBBS², Muhammad Ansab, ¹, Maria Qadri, MBBS³, Mahnoor Fatima, MBBS⁴, Ayesha Younas, MBBS⁵, Zain Sadiq, MBBS², Navkirat Kahlon, MD⁶, Faryal Altaf, MD⁷, Zaheer Qureshi, MD⁸
1Services Institute of Medical Sciences, Lahore, Punjab, Pakistan; 2Quaid-e-Azam Medical College, Bahawalpur, Punjab, Pakistan; 3Jinnah Sindh Medical University, Karachi, Sindh, Pakistan; 4King Edward Medical University, Lahore, Punjab, Pakistan; 5Allama Iqbal Medical College, Lahore, Punjab, Pakistan; 6Mass general cancer center at Wentworth Douglass Hospital, Dover, NH; 7BronxCare Health System, Bronx, NY; 8The Frank H. Netter M.D. School of Medicine at Quinnipiac University, Bridgeport, CT

Introduction: Metastatic colorectal cancer (mCRC) is a leading cause of cancer-related mortality worldwide. Intensified chemotherapy with FOLFOXIRI (5-fluorouracil, leucovorin, oxaliplatin, and irinotecan) combined with targeted agents has shown promising outcomes in mCRC patients. This meta-analysis compares the efficacy and safety of FOLFOXIRI plus cetuximab versus FOLFOXIRI plus bevacizumab in patients with mCRC to inform clinical decision-making and personalized treatment.

Methods: A literature search was conducted across PubMed, Cochrane, Embase, Scopus, and clinicaltrials.gov from inception till February 2025. Four studies evaluating FOLFOXIRI plus cetuximab vs. FOLFOXIRI plus bevacizumab were included. Analysis was performed using R Studio version v4.4.5. Pooled outcome estimates are reported as mean difference (MD), hazard ratio (HR), and odds ratio (OR), and 95% CI using the random effect model. Statistical heterogeneity was assessed using I² and X² statistics.

Results: Four studies with 561 patients were included in our study. Overall survival between FOLFOXIRI plus cetuximab vs FOLFOXIRI plus bevacizumab was not statistically significant (HR: 1.22; 95% CI: 0.78 –1.90; p = 0.386, I² = 49%). Progression-free survival (PFS) was significantly higher in the cetuximab arm (HR: 1.79; 95% CI: 1.21-2.63; p = 0.003; I² = 0%). Objective response rate, complete response, and partial response also did not differ significantly [(OR: 1.48; 95% CI: 0.58 – 4.93; p = 0.4772; I² = 66.7%), (OR: 1.59; 95% CI: 0.66-3.86; I² = 0%), and (OR: 1.60; 95%CI: 0.5, p = 0.62; I² = 73%) respectively]. Depth of response showed no significant difference (MD: 15.29; 95% CI: -1.35 – 31.94; p = 0.07). Hypomagnesemia and rash acneiform were the most notable adverse events with cetuximab (p < 0.01). However, alopecia, anemia, neurotoxicity, and stomatitis showed no difference between the two arms.

Discussion:

FOLFOXIRI plus cetuximab improved PFS in patients with mCRC but showed no significant overall survival and response rates than the bevacizumab combination; however, with increased toxicity. Treatment should be personalized based on tumor biology and patient tolerance.

Disclosures:
Ahmed Raza indicated no relevant financial relationships.
Faiza Fatima indicated no relevant financial relationships.
Muhammad Saffi Ullah indicated no relevant financial relationships.
Muhammad Ansab indicated no relevant financial relationships.
Maria Qadri indicated no relevant financial relationships.
Mahnoor Fatima indicated no relevant financial relationships.
Ayesha Younas indicated no relevant financial relationships.
Zain Sadiq indicated no relevant financial relationships.
Navkirat Kahlon indicated no relevant financial relationships.
Faryal Altaf indicated no relevant financial relationships.
Zaheer Qureshi indicated no relevant financial relationships.

Ahmed Raza, ¹, Faiza Fatima, MBBS¹, Muhammad Saffi Ullah, MBBS², Muhammad Ansab, ¹, Maria Qadri, MBBS³, Mahnoor Fatima, MBBS⁴, Ayesha Younas, MBBS⁵, Zain Sadiq, MBBS², Navkirat Kahlon, MD⁶, Faryal Altaf, MD⁷, Zaheer Qureshi, MD⁸. P0313 - Efficacy and Safety of FOLFOXIRI Plus Cetuximab versus FOLFOXIRI Plus Bevacizumab for Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.