P0261 - Increasing State-Level Burden of Early Onset Colorectal Cancer in the United States: A Systematic Analysis From Global Burden of Disease 1980-2021

Thanathip Suenghataiphorn, MD¹, Peenaprapa Tangpradubkiat, MD², Rinrada Worapongpaiboon, MD³, Narathorn Kulthamrongsri, MD⁴, Pojsakorn Danpanichkul, MD⁵, Rohit Singhania, MD⁶
1Griffin Hospital, Derby, CT; 2King Chulalongkorn Memorial Hospital, Bangkok, Krung Thep, Thailand; 3Johns Hopkins University School of Medicine, Baltimore, MD; 4University of Hawaii, Honolulu, HI; 5Department of Internal Medicine, Texas Tech University Healt, Lubbock, TX; 6Connecticut GI, Hartfort, CT

Introduction: Early-onset colorectal cancer (EOCC, diagnosed < 50 years) incidence is rising in the US. Understanding burden distribution across specific younger age groups, states, and metrics (incidence, mortality, disability-adjusted life years [DALYs]) is crucial for targeted interventions. We analyzed trends and state-level disparities in US colorectal cancer burden across these younger age groups.

Methods: We utilized state and national colorectal cancer incidence (1990-2021), mortality (1980-2021), and DALY (1990-2021) rate estimates (per 100,000) from the Global Burden of Disease (GBD) 2021 study. Data were analyzed for seven fine age strata (< 20, 20-24, 25-29, 30-34, 35-39, 40-44, 45-49 years). Trends were assessed visually; state variations were compared using 2021 rates.



Results: National average incidence rates increased consistently since 1990 from age 25-29 through 45-49 years. Conversely, national mortality and DALY rates initially declined but showed sustained increases post-early/mid-2000s, primarily affecting the 30–49-year age range. Significant state-level disparities existed across all metrics, widening with age and most pronounced in the 45-49 stratum in 2021. Higher burdens frequently clustered in Southern and Appalachian states, particularly from age 30 upwards.

Discussion: Colorectal cancer burden is increasing across distinct young adult age groups (incidence from 25+, mortality/DALYs recently from 30+). Profound, geographically patterned state-level disparities exist. Findings underscore the need for age-specific research, heightened clinical suspicion extending into younger adulthood (especially 30+), and targeted public health strategies in high-burden states


Figure: State Highlights for Colorectal Cancer by Age Group, Incidence Rate

Disclosures:
Thanathip Suenghataiphorn indicated no relevant financial relationships.
Peenaprapa Tangpradubkiat indicated no relevant financial relationships.
Rinrada Worapongpaiboon indicated no relevant financial relationships.
Narathorn Kulthamrongsri indicated no relevant financial relationships.
Pojsakorn Danpanichkul indicated no relevant financial relationships.
Rohit Singhania indicated no relevant financial relationships.

Thanathip Suenghataiphorn, MD¹, Peenaprapa Tangpradubkiat, MD², Rinrada Worapongpaiboon, MD³, Narathorn Kulthamrongsri, MD⁴, Pojsakorn Danpanichkul, MD⁵, Rohit Singhania, MD⁶. P0261 - Increasing State-Level Burden of Early Onset Colorectal Cancer in the United States: A Systematic Analysis From Global Burden of Disease 1980-2021, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.