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Sunday Poster Session

Category: Biliary/Pancreas

P0040 - Pancreatic Adenocarcinoma and Type 2 Diabetes Mellitus: Rising Mortality Trends in the United States

Sunday, October 26, 2025
3:30 PM - 7:00 PM MT
Location: Exhibit Hall
Zubia Zaman, MBBS1, Samreen Jawaid, MD2, Ambar Godoy, MD2, Daniel Guifarro Rivera, MD3, Daniela M. Montalvan-Sanchez, MD4, Fortunato S. Principe-Meneses, MD5, Namra Pasha, MBBS6, Eleazar E.. Montalvan-Sanchez, MD7
1Dow Medical College, Karachi, Sindh, Pakistan; 2Indiana University, Indianapolis, IN; 3Cook County Health and Hospital Systems, Chicago, IL; 4Universidad Autónoma de Honduras, Tegucigalpa, Francisco Morazan, Honduras; 5Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Lima, Peru; 6Karachi Medical and Dental College, Karachi, Sindh, Pakistan; 7Yale University School of Medicine, New Haven, CT

Introduction: Pancreatic cancer (PC) is the third leading cause of cancer deaths in the U.S. Type 2 diabetes (T2DM) is both a risk factor for and result of PC, linked to higher PC mortality. However, temporal and demographic patterns of PC and T2DM mortality in the U.S. are unclear. This study used national data to analyze mortality trends of PC and T2DM in the adult US population from 2001 to 2020.

Methods: Mortality data from the CDC WONDER database were analyzed for pancreatic adenocarcinoma and T2DM from 2001 to 2020 among adults aged 25 and above. Age-adjusted mortality rates (AAMRs) per 1,000,000 individuals were calculated. Annual percent change (APC) and average annual percent change (AAPC) were determined using Joinpoint regression, with trends stratified by year, sex, race/ethnicity, urbanization, and geographic region.

Results: From 2001 to 2020, there were 20,095 deaths due to pancreatic adenocarcinoma and diabetes in individuals ≥ 25 in the U.S. with an overall AAMR 4.5. The AAMR increased from 2.7 in 2001 to 4.1 in 2008 (APC 4.91), increased to 4.0 in 2014 (APC 0.61), and then increased to 7.4 in 2020 (APC 10.42; AAPC 5.22). Males had a higher mortality rate than females throughout (AAMR Male:5.6; Female 3.7). Both had a consistent increase from 2001 to 2020 (AAPC Male: 5.19; Female 4.84). Hispanics had a higher AAMR than non-Hispanic (NH) Black individuals and NH White (AAMR Hispanic 5.6; NH Black 5.4; NH White: 4.4). Hispanics had the highest increase from 2001 to 2020. (AAPC Hispanic 6.28; NH White: 4.92; NH Black 3.46;). Regionally, West had the highest mortality rate (AAMR West: 6.2) followed by Midwest (AAMR: 5.1), South (AAMR: 3.8) and Northeast (AAMR: 3.3). The West also had the highest AAPC (AAPC West 6.92; South 4.94; Northeast 3.28; Midwest: 3.27). Nebraska reported the highest state AAMR (8.8), and Nevada had the lowest (AAMR: 1.6). Rural areas had a higher AAMR than urban areas (AAMR Nonmetro 5.5; Metro 4.3). Visual trends are illustrated in Figure 1.

Discussion: Mortality from PC and T2DM has consistently increased among U.S. adults. Elevated rates in Hispanic and NH Black populations highlight the need for targeted policies to improve treatment access and address modifiable risks. Higher rural mortality may reflect limited imaging and screening access. These findings emphasize the urgent need for equitable access to early diagnosis and treatment, particularly in underserved rural and minority populations disproportionately affected by rising pancreatic cancer mortality.



Figure: Figure 1: Pancreatic Cancer and Type 2 Diabetes: Age-Adjusted Mortality Rates (AAMR) per 1,000,000, Stratified by Sex, Race, Census Region, and Urban-Rural Status, 2001-2020.


Figure: AAMR of Pancreatic Cancer And Type 2 DM Among Adults in the US from 2001-2020


Disclosures:
Zubia Zaman indicated no relevant financial relationships.
Samreen Jawaid indicated no relevant financial relationships.
Ambar Godoy indicated no relevant financial relationships.
Daniel Guifarro Rivera indicated no relevant financial relationships.
Daniela M. Montalvan-Sanchez indicated no relevant financial relationships.
Fortunato S. Principe-Meneses indicated no relevant financial relationships.
Namra Pasha indicated no relevant financial relationships.
Eleazar Montalvan-Sanchez indicated no relevant financial relationships.

Zubia Zaman, MBBS1, Samreen Jawaid, MD2, Ambar Godoy, MD2, Daniel Guifarro Rivera, MD3, Daniela M. Montalvan-Sanchez, MD4, Fortunato S. Principe-Meneses, MD5, Namra Pasha, MBBS6, Eleazar E.. Montalvan-Sanchez, MD7. P0040 - Pancreatic Adenocarcinoma and Type 2 Diabetes Mellitus: Rising Mortality Trends in the United States, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.