P0279 - Effect of Hormone Replacement Therapy on Outcomes of Hospitalized Postmenopausal Colorectal Cancer Patients: A Nationwide Analysis

Satya Lakshmi Vakalpudi, MBBS¹, Gurpreet Kaur, MBBS², Sreeraj Nair, MBBS³, Jeevan Mani Charan, MBBS⁴, Adarsh Sajan, MBBS⁵, Ruchita Wahane, MBBS⁶, Ronak Jain, MBBS⁷, Krishaa Nandini, MBBS⁸, Chandini Madeswaran, MD⁹, Smit Kotadiya, MBBS¹⁰, Deep Mehta, MD, MSCR¹¹, Amita Kasar, MD¹², Urvish Patel, MD, MPH¹³, Meghana Kakarla, MD¹⁴
1GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India; 2King Edward Medical University, Mumbai, Maharashtra, India; 3Ashwini Rural Medical College Hospital and Research Center, Kumbhari, Maharashtra, India; 4Apollo Institute of Medical Sciences and Research Center, Hyderabad, Telangana, India; 5Indepedent Author, Banglore, Karnataka, India; 6Grant Government Medical College and Sir J J Group of Hospitals, Mumbai, Maharashtra, India; 7Dr Ulhas Patil Medical College and Hospital, Jalgaon, Madhya Pradesh, India; 8RajaRajeswari Medical College and Hospital, Kambipura, Karnataka, India; 9MetroHealth Medical Center, Cleveland, OH; 10GMERS Medical College and Hospital, Junagadh, Junagadh, Gujarat, India; 11One Brooklyn Health-Interfaith Medical Center, Brooklyn, NY; 12Poplar Bluff Regional Medical center, Poplar Bluff, MO; 13Icahn School of Medicine at Mount Sinai, New York, NY; 14Infirmary Health, Mobile, AL

Introduction: Previous studies have shown that postmenopausal hormone replacement therapy (HRT) which is commonly prescribed to
postmenopausal women has been associated with reduced prevalence of colorectal cancer (CRC). Moreover small studies have also found that HRT could improve prognosis of CRC in postmenopausal women however data is very limited. Hence, we sought to analyze the association of HRT with CRC outcomes from the largest US population based cohort.

Methods: National Inpatient Sample (NIS) and Healthcare Cost and Utilization Project (HCUP) data from the year 2020 was queried to identify postmenopausal women hospitalizations with concurrent diagnosis of HRT and CRC. Other diagnoses of interests and comorbidities were identified by previously validated ICD-10-CM codes. Outcomes of interest were all-cause in-hospital mortality and discharge to facilities. We performed weighted analysis using multivariable survey logistic regression to estimate the impact of HRT on outcomes of hospitalized patients with CRC.

Results: We identified a total of 521,675 hospitalizations among postmenopausal CRC patients. Out of which 430,025 (82.4%) had long term use of HRT. Median age was 70 vs 73 (p< 0.01) and Caucasians were 80.8% vs 72% (p< 0.01) among the HRT group vs non-HRT. In unadjusted analysis, HRT was associated with lower in-hospital mortality (2.2% vs 4.4%; p< 0.01) but higher discharge to facility (24.2% vs 17.1%; p< 0.01). After adjusting for demographics, hospital-level characteristics, risk of mortality and confounding factors, HRT was independently associated with lower in-hospital mortality (aOR 0.5; 95%CI 0.5- 0.6; p< 0.01) but higher discharge to facility (aOR 1.6; 95%CI 1.4-1.6, p< 0.01).

Discussion: Our study concludes that long term use of postmenopausal HRT is associated with lower all-cause mortality among hospitalized CRC patients. Our findings are consistent with prior studies. Given limitations of large data, further studies are required to establish causality and in-depth analysis.


Figure: Impact of Hormone Replacement Therapy (HRT) on Outcomes in Hospitalized Postmenopausal Women with Colorectal Cancer (CRC)

Disclosures:
Satya Lakshmi Vakalpudi indicated no relevant financial relationships.
Gurpreet Kaur indicated no relevant financial relationships.
Sreeraj Nair indicated no relevant financial relationships.
Jeevan Mani Charan indicated no relevant financial relationships.
Adarsh Sajan indicated no relevant financial relationships.
Ruchita Wahane indicated no relevant financial relationships.
Ronak Jain indicated no relevant financial relationships.
Krishaa Nandini indicated no relevant financial relationships.
Chandini Madeswaran indicated no relevant financial relationships.
Smit Kotadiya indicated no relevant financial relationships.
Deep Mehta indicated no relevant financial relationships.
Amita Kasar indicated no relevant financial relationships.
Urvish Patel indicated no relevant financial relationships.
Meghana Kakarla indicated no relevant financial relationships.

Satya Lakshmi Vakalpudi, MBBS¹, Gurpreet Kaur, MBBS², Sreeraj Nair, MBBS³, Jeevan Mani Charan, MBBS⁴, Adarsh Sajan, MBBS⁵, Ruchita Wahane, MBBS⁶, Ronak Jain, MBBS⁷, Krishaa Nandini, MBBS⁸, Chandini Madeswaran, MD⁹, Smit Kotadiya, MBBS¹⁰, Deep Mehta, MD, MSCR¹¹, Amita Kasar, MD¹², Urvish Patel, MD, MPH¹³, Meghana Kakarla, MD¹⁴. P0279 - Effect of Hormone Replacement Therapy on Outcomes of Hospitalized Postmenopausal Colorectal Cancer Patients: A Nationwide Analysis, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.