Urmimala Chaudhuri, DO1, Sangeeta Agrawal, MD2 1Wright State University, Centerville, OH; 2Wright State University Boonshoft School of Medicine, Dayton, OH Introduction: Gastrointestinal bleeding (GIB) is a common cause of hospitalization in the United States, with sources originating from the upper or lower gastrointestinal tract. This study aimed to evaluate national trends in GIB-related mortality from 1999 to 2020, stratified by sex, race, and region to identify shifting demographic patterns. Methods: Mortality data was extracted from CDC WONDER and stratified by sex, race, and U.S. Census region. The findings were reported as age-standardized mortality rates. We used Joinpoint regression analysis (v5.20) to compute the annual percentage change (APC) and average annual percentage change (AAPC) for each subgroup, with significance set at p< 0.05. Results: Among females, GIB mortality declined significantly between 2003-2007 (APC: -5.36%, p< 0.05), then remained stable through 2018, then increased from 2018-2020 (APC: 4.10%, p< 0.05). Among males, there was a significant decrease in GIB from 2001-2009 with an APC of -3.08% (p< 0.05). Similar to females, males experienced an overall decline in mortality from 1999 to 2020.
By race, American Indians saw a consistent decline (APC of -1.55%, p< 0.05). Mortality decreased for Blacks from 1999-2010 (APC of -2.94%, p< 0.05) and then stabilized from 2010 to 2020. Among Whites, there was a significant increase in GIB mortality rates from 2009 to 2020 with an APC of 1.03% (p< 0.05).
We also examined the trends in mortality rates by region. In the Northeast, there was a significant increase in GIB from 2009 to 2020 with an APC of 0.84% (p< 0.05). Similarly in the West, from 2018 to 2020 there was a sharp increase in GIB with an APC of 6.72% (p< 0.05). GIB mortality rates in the South and Midwest showed non-significant declines over the full period. Discussion: GIB-related mortality has shown varying trends across sex, race, and region over the past two decades in the US. While the overall GIB mortality rates have declined among both sexes, there have been recent increases in GIB rates among females, Whites, and the Northeast and West regions. These subgroup-specific disparities highlight the need for renewed surveillance and targeted interventions to prevent worsening outcomes.
Figure: Figure 1. Joinpoints for GIB mortality by race
Figure: Figure 2. Joinpoints for GIB mortality by region
Disclosures: Urmimala Chaudhuri indicated no relevant financial relationships. Sangeeta Agrawal indicated no relevant financial relationships.
Urmimala Chaudhuri, DO1, Sangeeta Agrawal, MD2. P0914 - Shifting Patterns in Gastrointestinal Bleeding Mortality: Insights From a 20-Year US Study, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
