Zubia Zaman, MBBS1, Samreen Jawaid, MD2, Tarek G.. Aridi, MD3, Daniela M. Montalvan-Sanchez, MD4, Eleazar E.. Montalvan-Sanchez, MD5 1Dow Medical College, Karachi, Sindh, Pakistan; 2Indiana University, Indianapolis, IN; 3Indiana University School of Medicine, Indianapolis, IN; 4Universidad Autónoma de Honduras, Tegucigalpa, Francisco Morazan, Honduras; 5Yale University School of Medicine, New Haven, CT Introduction: Type 2 Diabetes Mellitus (T2DM) is associated with an increased risk of Hepatocellular Carcinoma (HCC) prevalence and mortality. However, the temporal and demographic patterns of HCC and T2DM mortality in the United States are not well known. With the increasing prevalence of T2DM and metabolic syndrome, analyzing mortality trends will help identify high risk populations, and guide targeted public health initiatives to improve clinical outcomes. In this study, we leveraged a large national database to analyze mortality trends from 2005 to 2020. Methods: Mortality data from the CDC WONDER database were analyzed for HCC and T2DM from 2005 to 2020 among adults aged 25 and above. Age-adjusted mortality rates (AAMRs) were calculated per 1,000,000 individuals. Annual percent change (APC) and average annual percent change (AAPC) were computed using Joinpoint regression. Trends were stratified by year, sex, race/ethnicity, urbanization status, and geographic region. Results: From 2005 to 2020, there were 5,748 HCC and T2DM related deaths among individuals aged 25 and above in the United States, with an overall AAMR of 1.5. The AAMR increased from 0.8 in 2005 to 1.2 in 2012 (APC 2.35), and to 2.5 in 2020 (APC 9.63; AAPC 6.17). Males had a higher AAMR than females (overall AAMR Male: 2.5; Female: 0.7). Both had a parallel increase from 2005 to 2020 (AAPC Male: 6.35; Female: 5.18). Hispanics had a higher AAMR than non-Hispanics (NH) (overall AAMR Hispanics 3.6; NH: 1.3). Both had a parallel increase from 2005 to 2020 (AAPC Hispanic: 5.81; NH: 6.05). Regionally, the West had the highest mortality rate (AAMR West: 2.6; Midwest: 1.5; South: 1.2; Northeast: 0.9). The West also had the highest increase in mortality from 2005 to 2020 (AAPC West: 6.64; South: 5.39; Northeast: 3.44; Midwest: 3.17). California reported the highest mortality rate (overall AAMR: 3.2). There was no difference in mortality rates between urban and rural areas (overall AAMR 1.5). Visual trends are illustrated in Figure 1. Discussion: Mortality from HCC and T2DM has increased among adults from 2005 to 2020, revealing significant sociodemographic disparities. The highest mortality rate was observed among Hispanic individuals and men, and among patients living in the West and nonmetropolitan United States. Targeted strategies are needed to improve treatment access and address modifiable risk factors.
Figure: Figure 1
Figure: AAMR of HCC And Type 2 DM Among Adults in the US from 2005-2020
Disclosures: Zubia Zaman indicated no relevant financial relationships. Samreen Jawaid indicated no relevant financial relationships. Tarek Aridi indicated no relevant financial relationships. Daniela M. Montalvan-Sanchez indicated no relevant financial relationships. Eleazar Montalvan-Sanchez indicated no relevant financial relationships.
Zubia Zaman, MBBS1, Samreen Jawaid, MD2, Tarek G.. Aridi, MD3, Daniela M. Montalvan-Sanchez, MD4, Eleazar E.. Montalvan-Sanchez, MD5. P1548 - Trends and Disparities in Hepatocellular Carcinoma and Type 2 Diabetes Mellitus Mortality in the United States: A Nationwide Analysis, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
