P2187 - Racial Disparities in Head of Pancreas Cancer: A SEER Database Analysis

Riddhi Machchhar, DO¹, Taylor Carmichael, ², Fatima Mossolem, ², Ahmed Dawood. Al Mahrizi, ³, Keerthana Bondugula, MD¹, Alexandra Greenberg, DO¹
1Hackensack Meridian OUMC, Brick, NJ; 2Rowan University School of Osteopathic Medicine, Voorhees, NJ; 3University of Malta Faculty of Medicine & Surgery, Msida, Malta

Introduction: 80 % of pancreatic cancers originate at the head of the pancreas and are highly metastatic due to it being diagnosed later on in the disease course. We hope to explore and highlight some of the racial disparities that impact survival in patients diagnosed with head of pancreas cancer.

Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Database was used to identify non-Hispanic White, Black, Asian, Hawaiian, and Pacific Islander (AAPI) patients diagnosed with malignant, histologically confirmed pancreatic head cancers between 1975 and 2021. A pair plot and scatter-plot with a regression line were used to analyze racial disparities in survival outcomes.

Results: ASurvival outcomes in male patients with pancreatic head cancer revealed significant racial disparities: At 12 months, a statistically significant difference in survival was observed between White and Black groups (p= 0.000257, z= -3.47), though the magnitude of this disparity decreased at subsequent time points. Comparisons between White and AAPI groups demonstrated significant differences at 12 months (p= 0.032, z= 2.13), 36, 48, and 60 months (p= 0.003, 0.047, and 0.023, respectively). The analysis of Black vs AAPI populations revealed significant differences across all time points, beginning at 12 months (p=0.000029, z= 4.02).

Discussion: Black males demonstrated significantly lower survival rates than White males at various time points, while White populations exhibited better survival outcomes compared to AAPI groups. Black populations showed better survival than AAPI groups. The long-term mortality between Black and White groups diminished over time, suggesting evolving dynamics in racial disparities. These findings underscore persistent racial disparities in pancreatic head cancer outcomes and highlight the need for targeted interventions that address healthcare access, socioeconomic barriers, and treatment disparities to improve survival across all populations.

Disclosures:
Riddhi Machchhar indicated no relevant financial relationships.
Taylor Carmichael indicated no relevant financial relationships.
Fatima Mossolem indicated no relevant financial relationships.
Ahmed Al Mahrizi indicated no relevant financial relationships.
Keerthana Bondugula indicated no relevant financial relationships.
Alexandra Greenberg indicated no relevant financial relationships.

Riddhi Machchhar, DO¹, Taylor Carmichael, ², Fatima Mossolem, ², Ahmed Dawood. Al Mahrizi, ³, Keerthana Bondugula, MD¹, Alexandra Greenberg, DO¹. P2187 - Racial Disparities in Head of Pancreas Cancer: A SEER Database Analysis, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.