Riddhi Machchhar, DO1, Keerthana Bondugula, MD1, Taylor Carmichael, 2, Fatima Mossolem, 2, Ahmed Dawood. Al Mahrizi, 3, Alexandra Greenberg, DO1 1Hackensack Meridian OUMC, Brick, NJ; 2Rowan University School of Osteopathic Medicine, Voorhees, NJ; 3University of Malta Faculty of Medicine & Surgery, Msida, Malta Introduction: Solid and papillary epithelial tumors (SPEN) of the pancreas are rare and typically benign cancers with a higher incidence in young non-white females. Evaluating racial disparities in pancreatic epithelial tumors can provide insights to better understand the underlying factors that contribute to survival differences. This understanding is critical for developing targeted interventions that can address these disparities and improve health outcomes in affected populations. Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Database was used to identify non-Hispanic White, Black, Asian, Hawaiian, and Pacific Islander patients (AAPI), diagnosed with pancreatic epithelial tumors cancers between 1975 and 2021. A pair plot and scatter plot with a regression line were used to analyze racial disparities in survival outcomes at 12, 24, 36, 48, and 60 months. Results: A comparative analysis of pancreatic epithelial tumors across different racial groups revealed significant disparities among minority patients. In male patients there is a significant difference in survival outcomes between White and Black groups (P-value < 0.05, z-score of -2.88) at 12 months only. Differences between the White and AAPI males and Black and AAPI male patients were consistent across all time points (p-value < 0.05). In females, significant differences in survival outcomes were found between White and Black groups at 36 (p-value = 0.011) and 48 months (p-value = 0.04). Black compared to AAPI female groups showed strong significant survival outcomes across all time points after diagnosis (p-value < 0.05). Discussion: Our findings reveal significant racial disparities in survival outcomes among patients with pancreatic epithelial tumors, particularly affecting Black and AAPI patient groups. These disparities may reflect differences in tumor biology, access to care, and timely diagnosis. More research needs to be done with diverse ethnicities with SPEN which is probably best classified as a neoplasm of borderline malignant potential.
Disclosures: Riddhi Machchhar indicated no relevant financial relationships. Keerthana Bondugula indicated no relevant financial relationships. Taylor Carmichael indicated no relevant financial relationships. Fatima Mossolem indicated no relevant financial relationships. Ahmed Al Mahrizi indicated no relevant financial relationships. Alexandra Greenberg indicated no relevant financial relationships.
Riddhi Machchhar, DO1, Keerthana Bondugula, MD1, Taylor Carmichael, 2, Fatima Mossolem, 2, Ahmed Dawood. Al Mahrizi, 3, Alexandra Greenberg, DO1. P2185 - Racial Disparities in Epithelial Tumors of the Pancreas: A SEER Database Analysis, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
