P2606 - Higher Bowel Preparation Adherence of SUTAB Over GoLYTELY During Outpatient Colonoscopy at a Tertiary Care Center

Charitha Karanam Ramapathy, MD¹, Mahmoud Aryan, MD², Shajan Peter, MD²
1UAB Montgomery, Montgomery, AL; 2University of Alabama at Birmingham, Birmingham, AL

Introduction: Bowel preparation is an important part of colonoscopy planning as inadequate preparation can lead to substandard procedures and need for repeat colonoscopy. Most recently SUTAB (sodium sulfate, magnesium sulfate, and potassium chloride) has emerged as an option in the form of oral tablets which are more tolerable.

Methods: We performed a prospective observational study at a tertiary care center. Patients were assigned either Golytely (polyethylene glycol 3350 and electrolytes oral solution) or SUTAB. Nursing staff and the endoscopists were blinded to bowel preparation allocation. Outcome variables including completion of bowel preparation and Boston Bowel Preparation Scale (BBPS) score were collected. Chi-Square test and logistic regression were used to measure patterns of association.

Results: A total of 2,791 patients were included, of which 2653 (95%) used Golytely and 137 (5%) used SUTAB. The study consisted of more females (55%) with Caucasian (52%) having an average age of 56.7 ± 12.7 years. Amongst the entire group, univariate logistic regression indicated that male gender, Caucasian race, and split bowel preparation all to be significantly associated with bowel preparation completion (all p< 0.05). Older age was associated with poor bowel preparation following logistic regression [OR: 1.02, 95% CI:1.00-1.03; p=0.001]. Those who used SUTAB were more likely to complete their bowel preparation compared to Golytely users (99% vs 94%, p=0.01). Multivariable logistic regression after controlling for age, race, gender, and split preparation administration further emphasized this positive association with SUTAB and completion of bowel preparation [OR: 8.7, CI:1.2-63.1; p=0.032]. Although a higher proportion of SUTAB users had better BPPS scores, difference was not statistically significant (70% vs 63%, p=0.119).

Discussion: Adequate bowel preparation is key to high quality colonoscopy. Our data indicates that compared to Golytely users, SUTAB users are likely to complete their bowel preparation. High proportion of SUTAB users had excellent BPPS scores which may be related to the better tolerability of SUTAB and ease of administration. Our study limitations with our smaller sample size in the SUTAB group may be related to the decreased availability of such medications to various demographic groups. Our results indicate tablet-based bowel preparation may translate to better adherence and tolerability as well as more effective bowel cleansing compared to liquid based preparation.

Disclosures:
Charitha Karanam Ramapathy indicated no relevant financial relationships.
Mahmoud Aryan indicated no relevant financial relationships.
Shajan Peter: Castle Bioscience – Advisory Committee/Board Member. Olympus – Advisory Committee/Board Member.

Charitha Karanam Ramapathy, MD¹, Mahmoud Aryan, MD², Shajan Peter, MD². P2606 - Higher Bowel Preparation Adherence of SUTAB Over GoLYTELY During Outpatient Colonoscopy at a Tertiary Care Center, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.