Menna-Allah Elaskandrany, DO1, Mohamed Ismail, DO2, Mahinaz Mohsen, MD2, Michael Bebawy, DO2, Sameer Rao, MBBS2, Ritik M. Goyal, MBBS2, Rohan Karkra, MBBS2, Weizheng Wang, MD2 1Lenox Hill Hospital, Northwell Health, New York, NY; 2Rutgers New Jersey Medical School, Newark, NJ Introduction: Although inflammatory bowel disease (IBD) is usually diagnosed in early adulthood, as the population ages, cardiovascular comorbidities such as coronary artery disease (CAD) are increasingly encountered in hospitalized patients with IBD. Although CAD is more prevalent among men in the general population, the impact of sex and age on CAD prevalence within the IBD population remains underexplored. We aimed to evaluate how age and sex correlate with the presence of CAD among hospitalized patients with IBD using a national dataset. Methods: We performed a retrospective cross-sectional analysis of 4,142,365 IBD-related hospitalizations from the National Inpatient Sample (2016–2019), identified using ICD-10 codes. Patients were stratified by the presence of CAD. Primary outcomes were mean age at admission and sex distribution. Group comparisons were performed using t-tests and Chi-square analysis, with statistical significance defined as p < 0.001. Results: CAD was present in 842,658 (20.3%) of all IBD-related hospitalizations. Patients with CAD were significantly older, with a mean age of 73.7 ± 11.4 years compared to 61.7 ± 18.0 years in those without CAD (p < 0.001), reflecting a 12-year absolute difference. Sex distribution also varied significantly by CAD status. Among IBD patients with CAD, 54.1% were male (n = 455,711) and 45.9% were female (n = 386,947), whereas in the non-CAD group, only 40.2% were male (n = 1,325,609) and 59.8% were female (n = 1,973,338). This represents a relative increase in the proportion of males among CAD patients compared to non-CAD patients, with the difference being statistically significant (Chi-square = 52,942, df = 1, p < 0.001). Discussion: Our findings reveal that hospitalized patients with IBD and concomitant CAD are significantly older and more likely to be male compared to their non-CAD counterparts. The observed difference in age underscores the cumulative cardiovascular burden in aging IBD populations, while the male predominance highlights potential sex-based differences in inflammatory response, cardiovascular risk factor distribution, and healthcare utilization. These disparities emphasize the need for proactive cardiac risk assessment, particularly in older males with IBD, and support the integration of geriatric and cardiovascular care strategies within IBD management. Future research should assess whether age- and sex-related interventions can improve outcomes in this population.
Figure: Age and Sex Distribution of Hospitalized IBD Patients Stratified by Coronary Artery Disease Status
Disclosures: Menna-Allah Elaskandrany indicated no relevant financial relationships. Mohamed Ismail indicated no relevant financial relationships. Mahinaz Mohsen indicated no relevant financial relationships. Michael Bebawy indicated no relevant financial relationships. Sameer Rao indicated no relevant financial relationships. Ritik M. Goyal indicated no relevant financial relationships. Rohan Karkra indicated no relevant financial relationships. Weizheng Wang indicated no relevant financial relationships.
Menna-Allah Elaskandrany, DO1, Mohamed Ismail, DO2, Mahinaz Mohsen, MD2, Michael Bebawy, DO2, Sameer Rao, MBBS2, Ritik M. Goyal, MBBS2, Rohan Karkra, MBBS2, Weizheng Wang, MD2. P3347 - Age and Sex Disparities in the Prevalence of Coronary Artery Disease Among Hospitalized Patients With Inflammatory Bowel Disease, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
