Metropolitan University College of Medicine Torrance, CA
Dhruv Gandhi, MD1, Siddidha Bokka, MD2, Wajdan Ahmad, MD3, Ayesha Cheema, MBBS3, Hareesha Rishab Bharadwaj, 4, Hassam Ali, MD5, Saqr Alsakarneh, MD, MSc6, Omar Al Ta’ani, MD7, Fariha Hasan, MD8, Sneh Sonaiya, MD, MPH, MBA9, Sheza Malik, MD10, Dushyant S. Dahiya, MD11, Syed Hasham Ali, MD12, Balamrit Singh Sokhal, MD13 1St Francis Medical Center, Monroe, LA, Mumbai, Maharashtra, India; 2Metropolitan University College of Medicine, Torrance, CA; 3Al-Tibri Medical College, Karachi, Sindh, Pakistan; 4The University of Manchester, Manchester, England, United Kingdom; 5East Carolina University/Brody School of Medicine, Greenville, NC; 6Mayo Clinic, Rochester, MN; 7Department of Internal Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania, USA, Pittsburgh, PA; 8Cooper University Hospital, Camden, NJ; 9Kirk Kerkorian School of Medicine at the University of Nevada Las Vegas, Las Vegas, NV; 10Emory University, Atlanta, GA; 11University of Kansas School of Medicine, Kansas City, KS; 12Dow University of Health Sciences, Karachi, Punjab, Pakistan; 13Royal Stroke University Hospital, Staffordshire, England, United Kingdom Introduction: To determine the trends and disparities in duodenal ulcer mortality in American adults older than 45 years between 1999-2020. Methods: Retrospective analysis of Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database was performed. For duodenal ulcer, International Classification of Diseases-10 code K26 was employed. Age-adjusted mortality rates(AAMR) and crude death rates(CDR) per 100,000 persons were determined. Average annual percentage change(AAPC) was determined using Joinpoint regression. Temporal trends were analyzed in sex, race, geographical distribution and patient age-related mortality. Results: A total of 28,134 deaths from duodenal ulcers were reported. AAMRs declined sharply from 1.5 to 0.97 between 1999-2008(AAPC:-5.75;p< 0.001) followed by a slight increase from 0.97 to 0.99 between 2008-2018(AAPC:0.4;p=0.46) and a sharper increase from 0.99 to 1.2 between 2018-2020(AAPC:10.33;p=0.07), resulting in an overall AAMR of 1.06(AAPC:-1.4;p=0.014). Males had higher AAMR(1.35) as compared to females(0.83) and showed a greater decline in mortality(AAPC:-1.95;p< 0.001) than females(AAPC:-0.88;p=0.38). Among races, non-Hispanic(NH) Whites had the highest AAMR(1.11) followed by NH Blacks(0.93), NH Asian/Pacific Islanders(0.92), NH American Indians/Alaskan Natives(0.79), and Hispanics(0.66). All races saw a decline in AAMR, with the greatest decline seen in NH Asian/Pacific Islanders(AAPC:-2.78;p=0.017). Geographically, AAMRs were highest in West(1.37) followed by Midwest(1.09). All census regions saw a decline in AAMR, with the greatest decline seen for Northeast(AAPC:-1.88;p=0.006). Nonmetropolitan areas showed a slightly higher AAMR(1.09) than metropolitan areas(1.05), although metropolitan areas saw a greater decline in AAMR(AAPC:-1.47;p=0.079) than nonmetropolitan areas(AAPC:-1.27;p=0.008). Of the 10-year age groups, CDR was highest for 85+ years(6.94). All age groups saw a decline in CDR, with the greatest decline seen for 85+years(AAPC:-2.31;p< 0.001) followed by 75-84 years(AAPC:-1.46;p=0.198). Discussion: We found a significant decline in duodenal ulcer mortality, though persistent disparities exist. Elderly males, NH Whites, residents of West and nonmetropolitan areas experienced disproportionately higher mortality rates. These findings emphasize the need for targeted interventions to address disparities and reduce mortality.
Figure: Trends based on Race
Figure: Trends based on Gender
Disclosures: Dhruv Gandhi indicated no relevant financial relationships. Siddidha Bokka indicated no relevant financial relationships. Wajdan Ahmad indicated no relevant financial relationships. Ayesha Cheema indicated no relevant financial relationships. Hareesha Rishab Bharadwaj indicated no relevant financial relationships. Hassam Ali indicated no relevant financial relationships. Saqr Alsakarneh indicated no relevant financial relationships. Omar Al Ta’ani indicated no relevant financial relationships. Fariha Hasan indicated no relevant financial relationships. Sneh Sonaiya indicated no relevant financial relationships. Sheza Malik indicated no relevant financial relationships. Dushyant Dahiya indicated no relevant financial relationships. Syed Hasham Ali indicated no relevant financial relationships. Balamrit Singh Sokhal indicated no relevant financial relationships.
Dhruv Gandhi, MD1, Siddidha Bokka, MD2, Wajdan Ahmad, MD3, Ayesha Cheema, MBBS3, Hareesha Rishab Bharadwaj, 4, Hassam Ali, MD5, Saqr Alsakarneh, MD, MSc6, Omar Al Ta’ani, MD7, Fariha Hasan, MD8, Sneh Sonaiya, MD, MPH, MBA9, Sheza Malik, MD10, Dushyant S. Dahiya, MD11, Syed Hasham Ali, MD12, Balamrit Singh Sokhal, MD13. P4035 - Trends and Disparities in Duodenal Ulcer Mortality in the United States Between 1999-2020, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
