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Monday Poster Session

Category: Liver

P3818 - Trends and Disparities in Hepatocellular Carcinoma Mortality Among Patients Aged 40 and Older in Texas: A Two-Decade Retrospective Study Using CDC WONDER Data

Monday, October 27, 2025
10:30 AM - 4:00 PM MT
Location: Exhibit Hall

    Presenting Author(s)

  • Kashif Ali, MD

    University of Texas Rio Grande Valley
    Edinburg, TX

Kashif Ali, MD1, Meghana Kakarla, MD2, Asif Zamir, MD, FACG3
1University of Texas Rio Grande Valley, Edinburg, TX; 2Infirmary Health, Mobile, AL; 3DHR Health Gastroenterology, Edinburg, TX

Introduction: Hepatocellular carcinoma (HCC) is on the rise due to increased incidence of cirrhosis in the US, more precisely in Texas due to multiple factors. HCC is one of the lethal complications of Liver cirrhosis and associated with high mortality and morbidity. This study aims to analyze mortality trends in HCC among patients older than 40 years in the state of Texas.

Methods: A study was conducted using CDC Wonder database by using ICD –10 codes for Hepatocellular carcinoma (C22.0). People older than 40+ years old were included in the study. Analysis was done to calculate the crude rate per 100,000 people. APC was calculated using Joint point software to estimate trends by calendar year, Sex, race, ethnicity and geographical area.

Results: From 1999 to 2020, a total of 17,008 patients died of HCC in Texas, with a continuous upward trend (APC: 2.74). Of these, 13,004 were males, and the remainder were females. Males had a consistent annual increase (APC: 2.95), while females initially showed a decline (APC: –2.49), followed by a rising trend (APC: 3.64) from 2006 to 2020.

Among racial groups, Asian or Pacific Islanders showed a significant annual decrease (APC: –2.7, p = 0.000017). Black or African American individuals had a significant increase (APC: 2.82, p = 0.000008). White individuals showed a notable annual increase (APC: 4.73) from 2007 to 2018, with no significant changes before or after this period.

Disparities were also observed between Hispanics and non-Hispanic individuals. Hispanics experienced a continuous rise in mortality with an annual increase of 1.28. Non-Hispanic individuals initially had a non-significant declining trend, followed by a consistent increase (APC: 2.06) from 2010 to 2020.

Geographically, all large metro and non-metro areas showed a continuous upward trend, with higher annual increases observed in smaller towns with APC 4.97% increased annually since 1999.

Discussion: Our study observed a continuous increase in HCC mortality in Texas. Since 2006, females have shown a greater rise in mortality compared to males. Hispanic/Latino populations are also experiencing a consistent upward trend. These findings highlight the importance of appropriate HCC screening in all patients with liver cirrhosis, which may help reduce both incidence and mortality.


Figure: Increasing trend in the mortality of HCC in Texas since 1999

Disclosures:
Kashif Ali indicated no relevant financial relationships.
Meghana Kakarla indicated no relevant financial relationships.
Asif Zamir indicated no relevant financial relationships.

Kashif Ali, MD1, Meghana Kakarla, MD2, Asif Zamir, MD, FACG3. P3818 - Trends and Disparities in Hepatocellular Carcinoma Mortality Among Patients Aged 40 and Older in Texas: A Two-Decade Retrospective Study Using CDC WONDER Data, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.