P3817 - Trends and Disparities in Mortality Rates From Alcoholic Liver Cirrhosis Among Hispanic and Latino Populations in the United States, 1999–2020: A CDC WONDER Study

Kashif Ali, MD¹, Meghana Kakarla, MD², Asif Zamir, MD, FACG³
1University of Texas Rio Grande Valley, Edinburg, TX; 2Infirmary Health, Mobile, AL; 3DHR Health Gastroenterology, Edinburg, TX

Introduction: There has been increase in mortality rates due to alcoholic liver cirrhosis. This study aims to analyse the trend in mortality since 1999-2020 among Hispanics and Latino population.

Methods: Mortality trends for adults aged >25 years were calculated using CDC Wonder dataset, identifying death rate through ICD-10 codes K70.30 for alcoholic liver cirrhosis. Crude rate per 100,000 and annual percent change (APC) with 95% confidence intervals were calculated using Joint point software.

Results: Our study shows that a total of 42,187 people have died in the United States from 1999 to 2020, the majority of whom were male (81.8%), with the remaining being female. Individuals aged 25–34 had an increasing annual percent change (APC) of 14.36 per 100,000 since 2011. Those aged 35–44 had the highest observed APC of 24.68% from 2018 to 2020. The 55–64 and 65–74 age groups showed APCs of 3.25% and 2.3%, respectively, starting in 2004. the West demonstrated a steady increase in mortality with an APC of 3.93% annually since 1999. The South showed an APC of 6.56% starting in 2009, while the Midwest experienced a sharper rise with an APC of 9.26% beginning in 2007. In the Northeast, there was a consistent increase with an APC of 4.3% from 2005 to 2020. large fringe metros, medium metros, and micropolitan areas showed increasing APCs of 7.85%, 6.3%, and 5.99%, respectively, beginning in 2009. Large central metros experienced an increased APC of 3.95% starting in 2003, and small metros showed a rise in mortality with an APC of 7.7% starting in 2011. White individuals had the most significant increase in mortality, with an APC of 12.1% starting in 2018. This was followed by American Indians, who showed an increasing mortality with APC of 3.5% per 100,000 since 2006.


Discussion: Our study shows a concerning rise in mortality rates across the United States. The highest mortality was observed among adults aged 35–44, followed by those aged 25–34. Large central metropolitan areas experienced the greatest increase in mortality. White individuals experienced a greater mortality trend compared to other racial groups. These findings highlight the need for further investigation and targeted public health interventions.


Figure: Trend in mortality rates among Hispanics and Latino aged >25 years old.

Disclosures:
Kashif Ali indicated no relevant financial relationships.
Meghana Kakarla indicated no relevant financial relationships.
Asif Zamir indicated no relevant financial relationships.

Kashif Ali, MD¹, Meghana Kakarla, MD², Asif Zamir, MD, FACG³. P3817 - Trends and Disparities in Mortality Rates From Alcoholic Liver Cirrhosis Among Hispanic and Latino Populations in the United States, 1999–2020: A CDC WONDER Study, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.