Mohammed Abusuliman, MD1, Agustin Gavidia Rosario, MD2, Ali Kadouh, MD2, Anju Pradeep, MD1, Razan Aburumman, MD2, Jared Klutke, MD1, Tobias Cox, MD3, Amr Abusuliman, MD4, Yara Dababneh, MD1, Remy Arwani, MD1, Muhammad Zarrar Khan, MD1, Syed-Mohammed Jafri, MD2 1Henry Ford Hospital, Detroit, MI; 2Henry Ford Health, Detroit, MI; 3Wayne State School of Medicine, Detroit, MI; 4Tanta University, Qutour, Al Gharbiyah, Egypt Introduction: Diabetes mellitus (DM) is a prevalent comorbidity among liver transplant (LT) candidates and has been associated with adverse postoperative outcomes in various solid organ transplants. However, its specific impact on post-LT clinical outcomes remains incompletely characterized. This study aimed to evaluate the association between pre-transplant diabetes status and key LT outcomes. Methods: We conducted a retrospective chart review on patients 18 years and older who underwent liver transplant at our center between 01/2015-01/2023. We identified all patients with pre-transplant DM and looked at multiple transplant outcomes, including mortality, episodes of rejection, need for re-transplantation, length of hospital stay following transplant, readmission rate within 1 year following transplant, emergent initiation of dialysis within 1 week of transplant, and graft failure. Results: A total of 807 patients underwent liver transplant, 526 were males (65%) and 667 were white (83%). All baseline characteristics are listed in (table 1). Among all patients, 336 (42%) had a history of diabetes mellitus. While there were no statistically significant differences between diabetic and non-diabetic patients in terms of mortality to date (23% vs. 19%, p = 0.2), graft rejection (22% vs. 25%, p = 0.4), graft failure (20% vs. 21%, p = 0.9), or re-transplantation rates (13% vs. 8.7%, p = 0.3), a significant difference was observed in the distribution of readmission frequency on the first year post-transplant (p = 0.046). Diabetic patients were more likely to experience multiple readmissions during the first year, with 17% having three and 22% having four or more readmissions, compared to 12% and 19% in non-diabetic patients, respectively. Overall readmission rates (65% vs. 60%, p = 0.11) and length of hospital stay (median 11 vs. 10 days, p = 0.3) were higher in diabetic patients but did not reach statistical significance (Table 2). Discussion: While diabetes mellitus was not associated with increased post-transplant mortality, graft failure, or rejection, it was significantly linked to a higher frequency of hospital readmissions within the first year after LT. These findings highlight the need for targeted perioperative care strategies and closer post-discharge monitoring in diabetic LT recipients to reduce healthcare burden and improve long-term outcomes.
Figure: Table 1: Baseline characteristics of liver transplant recipients (left and top right) and outcomes of liver transplantation based on diabetes status (bottom right)
Disclosures: Mohammed Abusuliman indicated no relevant financial relationships. Agustin Gavidia Rosario indicated no relevant financial relationships. Ali Kadouh indicated no relevant financial relationships. Anju Pradeep indicated no relevant financial relationships. Razan Aburumman indicated no relevant financial relationships. Jared Klutke indicated no relevant financial relationships. Tobias Cox indicated no relevant financial relationships. Amr Abusuliman indicated no relevant financial relationships. Yara Dababneh indicated no relevant financial relationships. Remy Arwani indicated no relevant financial relationships. Muhammad Zarrar Khan indicated no relevant financial relationships. Syed-Mohammed Jafri: Abbvie – Speakers Bureau. Gilead – Speakers Bureau. Intercept – Speakers Bureau. Ironwood – Speakers Bureau. Takeda – Speakers Bureau.
Mohammed Abusuliman, MD1, Agustin Gavidia Rosario, MD2, Ali Kadouh, MD2, Anju Pradeep, MD1, Razan Aburumman, MD2, Jared Klutke, MD1, Tobias Cox, MD3, Amr Abusuliman, MD4, Yara Dababneh, MD1, Remy Arwani, MD1, Muhammad Zarrar Khan, MD1, Syed-Mohammed Jafri, MD2. P5854 - Evaluating the Impact of Pre-Existing Diabetes on Liver Transplant Oucomes: A Single-Center Retrospective Study, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
