Zalika A. Ruddock-Scott, BSc1, Suriya B. Shanmugar, MBBS, MPH2, Urwa Nabilah, MBBS3, Bawanpreet Singh, MBBS4, Sudharsan Arul Sivakumar, MBBS5 1Caribbean Medical University, Toronto, ON, Canada; 2University of Massachusetts,Lowell, Nashua, NH; 3Shadan Institute of Medical Sciences, Hyderabad, Telangana, India; 4Kharkiv National Medical University, Brampton, ON, Canada; 5Nantong University Medical School, Madurai, Tamil Nadu, India Introduction: Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by a variety of symptoms that affect the digestive system. It is characterized by mild to chronic abdominal pain and altered bowel movements in the absence of a specific cause. Dietary modification is a component of symptom management, with fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet commonly used, however, it can be restrictive. This study evaluates the clinical, metabolic and biomarker outcomes of a sucrose-reduced diet (SSRD) in adults with IBS. Methods: We conducted a systematic review and meta-analysis of clinical trials focusing on the impact of SSRD in adults with IBS. Seven studies were included from a comprehensive literature search using PubMed, Cochrane Library, OpenMD, and Google Scholar (2015-present). Study quality and bias were assessed with Cochrane risk of bias Robins2. The outcomes included gastrointestinal symptoms, quality of life, psychological well-being and metabolic markers and inflammatory markers. Results: Most studies showed no significant differences in baseline characteristics between the intervention and control group (p > 0.05). After 6 months of SSRD, significant improvements were observed in abdominal pain (p< 0.001), diarrhea (p< 0.007), bloating (p< 0.001), vomiting (p= 0.04) and a total IBS-SSS score (p< 0.001) in intervention groups. Between-group comparisons at 6 months showed that SSRD significantly improved multiple gastrointestinal symptoms compared to controls. Improvements were also noted in extraintestinal symptoms, including fatigue, psychological well-being, and metabolic parameters (BMI, blood pressure, inflammatory markers), though with varying significance across studies. Discussion: Across all 7 studies, the SSRD diet from baseline to 6 months showed significant improvement across all primary and secondary outcomes. The SSRD appears to be a promising dietary intervention for adults with IBS, offering improvements not only in gastrointestinal symptoms but also in inflammatory and microbial markers. Further studies are needed that focus on a more diverse country patient population that is ethnicity-specific.
Disclosures: Zalika Ruddock-Scott indicated no relevant financial relationships. Suriya Shanmugar indicated no relevant financial relationships. Urwa Nabilah indicated no relevant financial relationships. Bawanpreet Singh indicated no relevant financial relationships. Sudharsan Arul Sivakumar indicated no relevant financial relationships.
Zalika A. Ruddock-Scott, BSc1, Suriya B. Shanmugar, MBBS, MPH2, Urwa Nabilah, MBBS3, Bawanpreet Singh, MBBS4, Sudharsan Arul Sivakumar, MBBS5. P5457 - Clinical and Molecular Effects of a Reduced Starch and Sucrose Diet in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
