P6334 - Temporal Trends in the Incidence of Gastroesophageal Reflux Disease and Peptic Ulcer Disease in the United Kingdom Over the Past 3 Decades

Ahmed A. Abdulelah, MD¹, Mohammad Alqaisieh, MD², Zaid A. Abdulelah, MD³
1Royal Papworth Hospital, Cambridge, England, United Kingdom; 2Hamilton Health Care System, Dalton, GA; 3Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, United Kingdom

Introduction: Peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) are among the most prevalent gastrointestinal diseases and impose a significant burden due to the associated morbidity and diminished quality of life. Therefore, it is of importance to evaluate the temporal trends in the incidence of PUD and GERD in the United Kingdom (UK) to identify areas requiring introduction of health policy measures

Methods: Temporal trends in the age-standardized incidence rate (ASIR) of GERD and PUD in the UK, and across the 4 nations (England, Wales, Scotland, and Northern Ireland), over the period 1990-2019 were evaluated by retrieving data from the Global Burden of Disease database. Joinpoint analysis was utilised to calculate the Annual Percent Change (AAPC) and the Average Annual Percent Change (AAPC).

Results: Over the period 1990-2019, an estimated total of 665,172 PUD cases with equal distribution between males and females were reported across the UK. A statistically significant decline in PUD ASIR was observed in the UK with an AAPC of -1.90 (95%CI -1.92 to -1.88, p< 0.001). Further analysis demonstrated a statistically significant decline in the ASIR across the 4 nations with the highest decline observed in Northern Ireland (AAPC -2.153, 95%CI -2.169 to -2.141, p< 0.001), closely followed by Scotland (AAPC -2.151, 95%CI -2.165 to -2.137, p< 0.001), Wales (AAPC -1.88, 95%CI -1.89 to -1.87, p< 0.001) and England (AAPC -1.87, 95%CI -1.89 to -1.86, p< 0.001). Stratification by gender revealed statistically significant decline in the ASIR in males (AAPC -1.95, 95%CI -1.96 to -1.93, p< 0.001) and females (AAPC -1.91, 95%CI -1.93 to -1.89, p< 0.001). In regard to GERD, a statistically nonsignificant change in the ASIR was observed in the UK with an AAPC of -0.015 (95%CI -0.029 to 0.001, p=0.06). Further analysis revealed a minimal, but statistically significant, change in the ASIR across the 4 nations. England experienced a statistically significant decline with an AAPC of -0.02 (95%CI -0.04 to -0.01, p=0.009). Northern Ireland, Scotland and Wales experienced a statistically significant minor decline in the ASIR with an AAPC of -0.002, -0.004 and -0.008, respectively.

Discussion: Over the period 1990-2019, the UK witnessed a statistically significant decline in the incidence of PUD across all 4 nations and in both males and females. On the other hand, the incidence of GERD did not undergo any significant change during the same period.

Disclosures:
Ahmed Abdulelah indicated no relevant financial relationships.
Mohammad Alqaisieh indicated no relevant financial relationships.
Zaid Abdulelah indicated no relevant financial relationships.

Ahmed A. Abdulelah, MD¹, Mohammad Alqaisieh, MD², Zaid A. Abdulelah, MD³. P6334 - Temporal Trends in the Incidence of Gastroesophageal Reflux Disease and Peptic Ulcer Disease in the United Kingdom Over the Past 3 Decades, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.