Texas Tech University Health Sciences Center - Permian Basin Odessa, TX
Ooreoluwa Fasola, MD1, Gloria Erazo, MD2, Jorge Rodriguez, MD1, Ahmed Bashir Sukhera, MD2, Eunice Aregbesola, MD3, Anjul Verma, MD2, Guy Loic Nguefang Tchoukeu, MD2, Godfrey Tabowei, MD4, Eunice Omeludike, MD5, Asley Sanchez, BSc1, John Garza, PhD1 1Texas Tech University Health Sciences Center - Permian Basin, Odessa, TX; 2Texas Tech University Health Sciences Center, Odessa, TX; 3University of Missouri , Columbia, Columbia, MO; 4Texas Tech University Health Science center, Permian Basin, Odessa, TX; 5Piedmont Athens Regional Medical Centre, Athens, GA Introduction: There is an increasing prevalence of patients with hepatocellular carcinoma (HCC) and concurrent diabetes mellitus (DM). The aim of this study was to investigate the association between a diagnosis of diabetes mellitus and in-hospital mortality in patients with hepatocellular carcinoma. Methods: A population-based cohort study of adults admitted to acute care hospitals in Texas during 2016 through 2023 with a diagnosis of HCC was completed using the Texas Inpatient Public Use Data File. The study population was identified using International Classifications of Diseases, Tenth Revisions, Clinical Modification (ICD-10-CM) code C220. The exposure was a diagnosis of DM identified using Clinical Classification Software Refined categories END004: Diabetes mellitus, Type 1 and END005: Diabetes mellitus, Type 2. The primary outcome was in-hospital mortality. Overlap propensity score weighting was the primary analysis approach. Results are reported as adjusted risk-ratio and 95% confidence interval (aRR [95% CI]). Figure 1 displays the overlap of propensity scores for hospitalizations with and without diabetes. Sensitivity analyses included hospitalizations aged ≥65 years, intensive care unit admissions, and hospitalizations with a diagnosis of cirrhosis. Results: A total of 40,130 hospitalizations were identified of which 16,325(40.7%) had DM. Compared to hospitalizations without DM, hospitalizations with DM were older (57.9% vs 43.7% aged ≥65 years), more often were diagnosed with nonalcoholic steatohepatitis (14.3% vs 4.5%), and more frequently had congestive heart failure (16.9% vs 10.5%). In-hospital mortality was substantially lower in hospitalizations with DM (6.2% vs 10.0%). On adjusted analysis, DM remained negatively associated with in-hospital mortality. Results of the primary and alternative analyses are presented in Figure 2. Similar results were observed on sensitivity analysis and for the secondary outcome of short-term mortality. Discussion: Our study showed that patients with HCC and DM were older and had comorbidities such as nonalcoholic steatohepatitis and congestive heart failure. However, they had lower in-hospital and short-term mortality compared to patients without DM. This may reflect differences in care provided during hospitalization. Further research is needed to understand protective factors associated with DM in context of in-hospital mortality.
Figure: Figure 1 - Propensity Score Overlap for Diabetes
Figure: Figure 2 - Association of diabetes and mortality in hospitalizations with hepatocellular carcinoma
Disclosures: Ooreoluwa Fasola indicated no relevant financial relationships. Gloria Erazo indicated no relevant financial relationships. Jorge Rodriguez indicated no relevant financial relationships. Ahmed Bashir Sukhera indicated no relevant financial relationships. Eunice Aregbesola indicated no relevant financial relationships. Anjul Verma indicated no relevant financial relationships. Guy Loic Nguefang Tchoukeu indicated no relevant financial relationships. Godfrey Tabowei indicated no relevant financial relationships. Eunice Omeludike indicated no relevant financial relationships. Asley Sanchez indicated no relevant financial relationships. John Garza indicated no relevant financial relationships.
Ooreoluwa Fasola, MD1, Gloria Erazo, MD2, Jorge Rodriguez, MD1, Ahmed Bashir Sukhera, MD2, Eunice Aregbesola, MD3, Anjul Verma, MD2, Guy Loic Nguefang Tchoukeu, MD2, Godfrey Tabowei, MD4, Eunice Omeludike, MD5, Asley Sanchez, BSc1, John Garza, PhD1. P3651 - The Association of Diabetes and Mortality in Hospitalizations With Hepatocellular Carcinoma: A Population-Based Cohort Study, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
