P3432 - Sex, Race, and Age Group Disparities in Digestive Diseases-Related Mortality Rates and Trends in the United States: Data From CDC Wonder 1999-2022

Diksha Kajal, MD¹, Avinash Nankani, MBBS², Rahul Kumar, MD³, Sunny Kumar, MD⁴, Muhammad Hamza Dawood, ⁵, Karan J.. Yagnik, MD⁶, Akshay Sharma, MBBS⁷, Abdus Sameey Anwar, MBBS⁸, Miroslav Radulovic, MD³
1Florida State University, Cape Coral, FL; 2Dow University of Health Sciences, Karachi, Sindh, Pakistan; 3North Central Bronx Hospital, Bronx, NY; 4Wright Center for Graduate Medical Education, Scranton, PA; 5United Medical and Dental College, Karachi, Sindh, Pakistan; 6Monmouth Medical Center, Robert Wood Johnson Medical School of Rutgers University, Long Branch, NJ; 7Luminis Health Anne Arundel Medical Center, Annapolis, MD; 8College of Medical Sciences, Bharatpur, Dhanbad, Jharkhand, India

Introduction: This study aimed to evaluate sex, race and age-related trends in mortality associated with digestive diseases (DD) among adults in the United States.

Methods: Mortality data from death certificates were extracted from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC-WONDER) database. The analysis included individuals aged ≥15 years with DD recorded as either the underlying or a contributing cause of death between 1999-2022. Age-adjusted mortality rates (AAMRs) per 100,000 population and annual percent change (APC) were computed and stratified by year, sex, race/ethnicity, and age group.

Results: Between 1999 and 2022, a total of 4,916,279 deaths due to DD were recorded among adults aged ≥25 years. The overall AAMR decreased from 84.9 in 1999 to 70.9 in 2010 (APC: -1.83, 95% CI: -2.52 to -1.47), followed by a period of stability until 2018 (AAMR: 71.8, APC: 0.17, 95% CI: -0.73 to 1.47), and a sharp increase thereafter, reaching 85.6 in 2022 (APC: 5.78, 95% CI: 4.19 to 8.47). Men exhibited consistently higher AAMRs (87.34) than women (61.30), with similar trends: a decline from 102.4 in 1999 to 84.5 in 2010 (APC: -1.88, 95% CI: -2.58 to -1.52) followed by stability until 2018 (AAMR: 85.5, APC: 0.24, 95% CI: -0.73 to 1.50), and a subsequent rise to 100.9 in 2022 (APC: 5.46, 95% CI: 3.88 to 8.44) for men, and from 70.7 in 1999 to 58.9 in 2011 (APC: -1.80, 95% CI: -2.37 to -1.49) followed by an increase to 72.1 in 2022 (APC: 5.90, 95% CI: 4.35 to 8.48) for women. Racial/ethnic disparities were noted, with American Indian or Alaska Native individuals having the highest mean AAMR (102.5), followed by Black or African American individuals (78.8). Both groups experienced declines from 1999 to 2018 (American Indian or Alaska Native: 113.8 to 98.2, APC: -0.41; Black or African American: 106.3 to 69.8, APC: -3.77), followed by sharp increases through 2020 (American Indian or Alaska Native: 130.4, APC: 11.19; Black or African American: 83.6, APC: 5.97). Age-stratified analysis revealed an initial decline in mortality across all age groups, followed by an increase in the subsequent decade, with the highest AAMRs in 2022 observed in the 76–85+ age group (460.8) and the 54–74 age group (162.5).

Discussion: Mortality from digestive diseases initially declined but has risen sharply in recent years, with disparities exist by sex, race, and age. These findings highlight the need for targeted interventions to address the growing burden.


Figure: Sex- and race-stratified trends in digestive disease mortality (1999–2022), showing higher AAMRs in males and American Indian or Alaska Native populations, with rising rates post-2018.


Figure: Age-stratified mortality trends from digestive diseases (1999–2022), with the highest AAMRs in adults aged ≥75 and increasing rates across all age groups after 2018.

Disclosures:
Diksha Kajal indicated no relevant financial relationships.
Avinash Nankani indicated no relevant financial relationships.
Rahul Kumar indicated no relevant financial relationships.
Sunny Kumar indicated no relevant financial relationships.
Muhammad Hamza Dawood indicated no relevant financial relationships.
Karan Yagnik indicated no relevant financial relationships.
Akshay Sharma indicated no relevant financial relationships.
Abdus Sameey Anwar indicated no relevant financial relationships.
Miroslav Radulovic indicated no relevant financial relationships.

Diksha Kajal, MD¹, Avinash Nankani, MBBS², Rahul Kumar, MD³, Sunny Kumar, MD⁴, Muhammad Hamza Dawood, ⁵, Karan J.. Yagnik, MD⁶, Akshay Sharma, MBBS⁷, Abdus Sameey Anwar, MBBS⁸, Miroslav Radulovic, MD³. P3432 - Sex, Race, and Age Group Disparities in Digestive Diseases-Related Mortality Rates and Trends in the United States: Data From CDC Wonder 1999-2022, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.