P3337 - Association of Post Procedural Complications and Length of Stay Among Hospitalized Patients with Crohn’s Disease: A Population-Based Cohort Study

Anjul Verma, MD¹, Avneet Kaur, MBBS², Guy Loic Nguefang Tchoukeu, MD¹, Edgar Luna Landa, MD¹, Hayden Mathews, BS³, Lauren Glover, ³, Megan Mobley, ³, Sachi Khemka, MBA, BS⁴, Virginia McGrath, BS³, Merry Mathew, BS³, John Garza, PhD⁵
1Texas Tech University Health Sciences Center, Odessa, TX; 2SUNY Upstate Medical University, Syracuse, NY; 3Texas Tech University Health Sciences Center School of Medicine, Odessa, TX; 4Texas Tech University Health Sciences Center, Amarillo, TX; 5Texas Tech University Health Sciences Center - Permian Basin, Odessa, TX

Introduction: Crohn’s disease (CD) is a chronic inflammatory bowel condition that often necessitates diagnostic and therapeutic gastrointestinal procedures. Postprocedural or postoperative complications can substantially increase healthcare resource utilization in this population. However, the impact of these complications on hospital-level outcomes among patients with CD remains poorly characterized. In this study, we aimed to evaluate the association between postprocedural digestive system complications and healthcare utilization.

Methods: We conducted a population-based cohort study using deidentified, publicly available data on adult hospitalizations to acute care hospitals for CD in Texas from Q1 2016 to Q2 2024. Elective admissions and inter-hospital transfers were excluded. CD hospitalizations were identified using ICD-10-CM codes (K52.0x) under CCSR category DIG011. The primary exposure was a diagnosis of post procedural or post operative digestive system complications identified using CCSR category DIG024. Primary outcomes included length of stay and inflation-adjusted total hospital charges. Overlap propensity score weighting was applied, and results were reported as adjusted risk ratios (aRR) with 95% confidence intervals.

Results: Of 78,858 CD-related hospitalizations, 3,739 (4.7%) had postprocedural complications. Compared to those without complications, these hospitalizations had lower rates of hypertension (28.2% vs 40.1%) and higher rates of malnutrition (53.6% vs 15.2%) (p < 0.0001). In the overlap-weighted cohort, complications were associated with longer hospital stays (8.92 vs 5.73 days; aRR 1.56 [95% CI, 1.49–1.63]) and higher total charges ($131,736 vs $86,833; aRR 1.52 [95% CI, 1.43–1.61]). These findings were consistent across subgroups undergoing colonoscopy with biopsy, small bowel resection, and diagnostic GI endoscopy.

Discussion: Postprocedural complications were associated with significantly longer hospital stays and higher total charges, even after adjustment for baseline characteristics. Our findings highlight the substantial clinical and economic burden of procedural complications in CD and underscore the need for targeted preventive strategies and risk mitigation efforts in this high-risk group.


Figure: The characteristics Crohn’s disease patients with and without post procedural and post operative digestive system complications


Figure: The association of post procedural and post operative digestive system complications and resource utilization in hospitalizations with Crohn's disease

Disclosures:
Anjul Verma indicated no relevant financial relationships.
Avneet Kaur indicated no relevant financial relationships.
Guy Loic Nguefang Tchoukeu indicated no relevant financial relationships.
Edgar Luna Landa indicated no relevant financial relationships.
Hayden Mathews indicated no relevant financial relationships.
Lauren Glover indicated no relevant financial relationships.
Megan Mobley indicated no relevant financial relationships.
Sachi Khemka indicated no relevant financial relationships.
Virginia McGrath indicated no relevant financial relationships.
Merry Mathew indicated no relevant financial relationships.
John Garza indicated no relevant financial relationships.

Anjul Verma, MD¹, Avneet Kaur, MBBS², Guy Loic Nguefang Tchoukeu, MD¹, Edgar Luna Landa, MD¹, Hayden Mathews, BS³, Lauren Glover, ³, Megan Mobley, ³, Sachi Khemka, MBA, BS⁴, Virginia McGrath, BS³, Merry Mathew, BS³, John Garza, PhD⁵. P3337 - Association of Post Procedural Complications and Length of Stay Among Hospitalized Patients with Crohn’s Disease: A Population-Based Cohort Study, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.