P2946 - High Burden of Psychiatric Comorbidities in Adults With Concomitant Functional Dyspepsia and Gastroparesis: A Multi-Center Analysis Using the TriNetX Network (2015-2025)

Archana Kharel, MD¹, Venkata Sunkesula, MD², Islam Mohamed, MD³, Umesh Bhagat, MD³, Prabhat Kumar, MD⁴, Gengqing Song, MD, PhD⁵
1Cleveland Clinic, Cleveland, OH; 2Case Western Reserve University / MetroHealth, Cleveland, OH; 3Cleveland Clinic Foundation, Cleveland, OH; 4Virginia Commonwealth University, Richmond, VA; 5Case Western Reserve University/Metro Health, Cleveland, OH

Introduction: Functional dyspepsia (FD) and gastroparesis frequently coexist and are each linked to impaired quality of life. Data describing the spectrum and magnitude of psychiatric comorbidity in patients who carry both diagnoses are scarce. We leveraged a large, federated electronic‐health-record network to describe the psychiatric profile of FD/GP patients and evaluate demographic disparities.

Methods: Using the TriNetX Research Network (100 U.S. healthcare systems), we identified adults (≥18 y) with FD (ICD-10-CM K30) and gastroparesis (K31.84) from 2015–2025. Psychiatric disorders were defined using ICD-10-CM codes: major depressive disorder (MDD: F32/F33), anxiety (F41.x), bipolar disorder (BPD: F31), schizophrenia/psychotic disorders (F20–F29), post-traumatic stress disorder (PTSD: F43.1), and obsessive-compulsive disorder (OCD: F42). Outcomes included incident proportion, period prevalence, and incidence rate (cases/person-day) stratified by age, sex, race, and ethnicity.

Results: The cohort included 38,966 FD/GP patients (median age 49 y; 63% female; 72% White). Overall prevalence was high for MDD (55.4%), anxiety (22.6%) followed by PTSD (10.2%), BPD (8.7%), OCD (2.8%) and lastly schizophrenia/psychotic disorders (1.7%). Females had higher prevalence for MDD (58.9% vs 45.6%), anxiety (24.9% vs 14.9%), BPD (9.8% vs 5.9%),PTSD (11.8% vs. 6%) and OCD (3.1% vs 2.0%) .MDD and BPD peaked at ages 35–39 years (60.1 % and 65.5 %, respectively), whereas OCD and PTSD were most common at ages 20–24 years. Pronounced racial and ethnic disparities were evident. Native Hawaiian/Other Pacific Islander patients showed the highest prevalence across all psychiatric conditions, while Asian patients had the lowest overall burden. Schizophrenia was comparatively infrequent in White patients, and OCD least common among Black patients.

Discussion: In this nationwide real-world cohort ,over half of patients with FD/GP carried major MDD and one-quarter carried GAD. Burden of disease was highest in women, concentrated in adolescence and young adulthood for mood-anxiety disorders. There was noted racial disparity with peaks in American Indian/Alaska Native and Native Hawaiian/Pacific Islander populations across most conditions, while Asian patients consistently showed the lowest prevalence. These patterns underscore the need for routine, culturally tailored mental-health screening and integrated gastro-psychiatric care, with particular vigilance for high-risk sex, age, and racial/ethnic groups.


Figure: Table:Prevalence, Demographic Variation, and Racial Disparities in Psychiatric Comorbidities Among Adults With Functional Dyspepsia and Gastroparesis.


Disclosures:
Archana Kharel indicated no relevant financial relationships.
Venkata Sunkesula indicated no relevant financial relationships.
Islam Mohamed indicated no relevant financial relationships.
Umesh Bhagat indicated no relevant financial relationships.
Prabhat Kumar indicated no relevant financial relationships.
Gengqing Song indicated no relevant financial relationships.

Archana Kharel, MD¹, Venkata Sunkesula, MD², Islam Mohamed, MD³, Umesh Bhagat, MD³, Prabhat Kumar, MD⁴, Gengqing Song, MD, PhD⁵. P2946 - High Burden of Psychiatric Comorbidities in Adults With Concomitant Functional Dyspepsia and Gastroparesis: A Multi-Center Analysis Using the TriNetX Network (2015-2025), ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.