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Tuesday Poster Session

Category: Biliary/Pancreas

P4331 - Exploring the Role of miRNA Expression Profiles in Severe Acute Pancreatitis-Associated Acute Lung Injury: Mechanisms, Biomarkers, and Therapeutic Insights

Tuesday, October 28, 2025
10:30 AM - 4:00 PM MT
Location: Exhibit Hall

    Presenting Author(s)

  • NS

    Neha Singh, MD

    NORTH ALABAMA MEDICAL CENTER
    Florence, AL

Neha Singh, MD1, Bhavana Baraskar, MD2, Rishika Trivedi, MD3, Helai Hussaini, MD4, Rupak Desai, MBBS5, Jyoti Yadav, MBBS6, Mohammed Mustafa Nayeem, MD7, Priyatham Gurram, MD8, Jithin Kolli, MBBS9
1NORTH ALABAMA MEDICAL CENTER, Florence, AL; 2Mary Washington Healthcare, Fredericksburg, VA; 3DHR Health, McAllen, TX; 4west anaheim medical center, Anaheim, CA; 5Independent Outcomes Researcher, Atlanta, GA; 6JSS Medical college, Mysore, Karnataka, India; 7University of Colorado- Parkview medical center, Pueblo, CO; 8Central Michigan University College of Medicine, Saginaw, MI; 9JSS MEDICAL COLLEGE, Andra Pradesh, Andhra Pradesh, India

Introduction: Severe acute pancreatitis (SAP) frequently results in complications like acute lung injury(ALI), which can substantially lead to adverse patient outcomes. Emerging research emphasizes the crucial role of microRNAs (miRNAs) in the mechanism underlying SAP-associated acute lung injury (ALI). This systematic review aims to enhance the current understanding of miRNA-mediated processes and their utility as a target for therapy or biomarkers in SAP-ALI

Methods: We performed a comprehensive search across the PubMed and Google Scholar databases for studies exploring the role of miRNA in SAP-ALI, following PRISMA guidelines. We included preclinical and clinical investigations defining miRNA expression profiles, functional analyses, or therapeutic interventions. Relevant data on study design, miRNA targets, pathways involved, and outcomes were collected and analyzed.

Results: A total of eleven studies were included, featuring animal models, patient-derived data, and cellular experiments. Findings indicated that certain miRNAs (such as miR-29a, miR-503-5p, miR-483-5p) are dysregulated in SAP-ALI, affecting inflammation, fibrosis, and altering immune response. miR-29a was associated with decreased fibroinflammatory responses, whereas miR-503-5p worsened the inflammatory response. The use of exosomes to deliver miRNA has demonstrated therapeutic potential in preclinical settings, with miRNAs like miR-181a-5p affecting key pathways, including the TLR4/NF-kB pathway. Studies based on patient data identified certain miRNAs(such as MiR-127, miR-1206b) as promising biomarkers for defining the severity and prognosis of SAP-ALI.

Discussion: This review highlights the important role of miRNAs in SAP-ALI pathogenesis and shows strong potential as both biomarkers and therapeutic targets. Future studies should focus on applying these findings to clinical settings to improve outcomes in SAP-ALI patients.


Figure:
BALF: Bronchoalveolar Lavage Fluid, miRNA: MicroRNA, EMO: Emodin, SAPALI: Severe Acute Pancreatitis-Associated Lung Injury, SAP: Severe Acute Pancreatitis, ALI: Acute Lung Injury, EVs: Extracellular Vesicles. MALAT1: Metastasis-Associated Lung Adenocarcinoma Transcript 1, TLR4: Toll-Like Receptor 4, HMGB1: High Mobility Group Box 1 Protein, AP: Acute Pancreatitis, SOCS5: Suppressor of Cytokine Signaling 5, TRIF: TIR-domain-containing Adapter Inducing Interferon-β, STAT3: Signal Transducer and Activator of Transcriptor 3, JAK2: Janus Kinase 2, MyD88: Myeloid Differentiation Primary Response Gene 88, SGB: Stellate Ganglion Block


Disclosures:
Neha Singh indicated no relevant financial relationships.
Bhavana Baraskar indicated no relevant financial relationships.
Rishika Trivedi indicated no relevant financial relationships.
Helai Hussaini indicated no relevant financial relationships.
Rupak Desai indicated no relevant financial relationships.
Jyoti Yadav indicated no relevant financial relationships.
Mohammed Mustafa Nayeem indicated no relevant financial relationships.
Priyatham Gurram indicated no relevant financial relationships.
Jithin Kolli indicated no relevant financial relationships.

Neha Singh, MD1, Bhavana Baraskar, MD2, Rishika Trivedi, MD3, Helai Hussaini, MD4, Rupak Desai, MBBS5, Jyoti Yadav, MBBS6, Mohammed Mustafa Nayeem, MD7, Priyatham Gurram, MD8, Jithin Kolli, MBBS9. P4331 - Exploring the Role of miRNA Expression Profiles in Severe Acute Pancreatitis-Associated Acute Lung Injury: Mechanisms, Biomarkers, and Therapeutic Insights, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.