Prime South GME Consortium/Harlingen Medical Center Program Rancho Cucamonga, CA
Award: ACG Presidential Poster Award
Raghava Rao Alluri, MD1, Rohan Talati, MBBS2, Sandeep Kotnani, MBBS3, Yashkumar Girdharlal Kamani, MD4, Mili H. Ashar, MBBS5, Prince Nileshkumar Modi, MBBS6, Juhi Patel, MBBS7, Vishrant Amin, MBBS, MD8, Hardik Desai, MBBS9 1Prime South GME Consortium/Harlingen Medical Center Program, Harlingen, TX; 2Pramukh Swami Medical College, Gokalnagar, Karamsad, Anand, Gujarat-, Aanand, Gujarat, India; 3Rutgers Monmouth Medical Center, Long Branch, NJ; 4BronxCare Health System, Bronx, NY; 5Rural Medical College, Loni, Maharashtra (Pravara Institute of Medical Sciences), Maharashtra, Maharashtra, India; 6Pramukh Swami Medical College, Gokalnagar, Karamsad, Anand, Aanand, Gujarat, India; 7GMERS Medical College and Hospital Valsad, Milltown, NJ; 8HMH JFK University Medical Center, Milltown, NJ; 9Independent Clinical and Public Health Researcher, Ahmedabad, Gujarat, India Introduction: A nationwide assessment was performed to track the burden of congenital digestive anomalies in the United States from 1990 to 2021 using standardized global burden of disease study 2021 framework. Age-standardized rates of prevalence, mortality, and disability-adjusted life years (DALYs), years lived with disability (YLDs) were analyzed per 100,000 population. Long-term trends were evaluated by calculating annualized percentage change (APC) using log-linear regression. All estimates were derived from globally harmonized epidemiological datasets and are presented with 95% uncertainty intervals. Methods: A nationwide assessment was performed to track the burden of congenital digestive anomalies in the United States from 1990 to 2021 using standardized global burden of disease study 2021 framework. Age-standardized rates of prevalence, mortality, and disability-adjusted life years (DALYs), years lived with disability (YLDs) were analyzed per 100,000 population. Long-term trends were evaluated by calculating annualized percentage change (APC) using log-linear regression. All estimates were derived from globally harmonized epidemiological datasets and are presented with 95% uncertainty intervals. Results: Between 1990 and 2021, the age-standardized incidence rate (ASIR) for congenital digestive anomalies in the United States increased by 0.58% annually, while the prevalence rate (ASPR) declined by 0.27%. The burden measured by age-standardized DALYs (ASDALR) and YLDs (ASYLDsR) decreased by 1.16% and 0.26%, respectively. Subnationally, the highest increase in ASIR was noted in Maine (APC: 1.57%), followed by Delaware (1.41%), Tennessee (1.32%), and Georgia (1.32%). ASPR was highest in Maine (0.33%), West Virginia (0.21%), and Montana (0.09%). Age-wise, the greatest prevalence was seen in the 2–4 years age group (17,456 [95% UI: 13,787–21,756]), while the highest DALY burden occurred in neonates aged 0–6 days (15,074 [11,725–17,929]). Males consistently exhibited a higher burden than females, with a steeper rise in ASIR (0.9% vs. 0.19%) and a slightly slower decline in ASYLDsR (–0.21% vs. –0.3%). Discussion: While mortality from congenital digestive anomalies has declined in the U.S., the overall burden remains substantial due to persistent disability and demographic disparities. Targeted interventions focused on early diagnosis, surgical access, and long-term follow-up are essential to reduce avoidable disability and ensure equitable outcomes.
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Disclosures: Raghava Rao Alluri indicated no relevant financial relationships. Rohan Talati indicated no relevant financial relationships. Sandeep Kotnani indicated no relevant financial relationships. Yashkumar Girdharlal Kamani indicated no relevant financial relationships. Mili H. Ashar indicated no relevant financial relationships. Prince Nileshkumar Modi indicated no relevant financial relationships. Juhi Patel indicated no relevant financial relationships. Vishrant Amin indicated no relevant financial relationships. Hardik Desai indicated no relevant financial relationships.
Raghava Rao Alluri, MD1, Rohan Talati, MBBS2, Sandeep Kotnani, MBBS3, Yashkumar Girdharlal Kamani, MD4, Mili H. Ashar, MBBS5, Prince Nileshkumar Modi, MBBS6, Juhi Patel, MBBS7, Vishrant Amin, MBBS, MD8, Hardik Desai, MBBS9. P1880 - Trends and Regional Disparities in Congenital Digestive Anomalies in the United States, 1990–2021, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
