Anhui Medical University, Hefei Hefei, Anhui, China
Rakhshanda Khan, MBBS1, Harshawardhan Dhanraj Ramteke, MBBS2, Ashesh Das, MBBS3, Dineshbaba Murugavel, MD4, Sai Manohar Raju Obbani, MBBS5, Phanish Chandra. Ravi, MBBS6, Anil Reddy Padi, MBBS7, Sri Mani Krishna Satvik Matta, MBBS8, Sonam Dhall, MBBS9, Vignesh Krishnadoss, 10, Joshua Mohanan, 11, Freny Lalchandani, 12, Sneha Baiju, MBBS13, Joshua Annamalai, MD14, Achind Anil Kumar, MD15, Maryem Filal, MBBS16, Ivin Thomas. Jolly, MBBBS2, Manish Madanlal. Juneja, DM, MD, MBBS17 1Ayaan institute of medical sciences, Moinabad, Telangana, India; 2Anhui Medical University, Hefei, Hefei, Anhui, China; 3KPC Medical College and Hospital , Kolkata, India, Kolkata, West Bengal, India; 4Tbilisi state university, Chennai, Tamil Nadu, India; 5DR. NTR university of health sciences, Guntur, Andhra Pradesh, India; 6SVS Medical College, Mahabubnagar, Telangana, India; 7Osmania General Hospital and Medical College, Hyderabad, Telangana, India; 8Siddhartha Medical College Vijayawada, Vijayawada, Andhra Pradesh, India; 9Dayanand Medical College and Hospital, Edison, NJ; 10Ivane javakishivili tbilisi state university, Chennai, Tamil Nadu, India; 11ivane javakhishvili tbilisi state university, Dharmapuri, Tamil Nadu, India; 12Tbilisi state medical university, Tbilisi, T'bilisi, Georgia; 13Jawaharlal Nehru Medical College, Belgaum, India, Kollam, Kerala, India; 14Tbilisi State Medical University, Tbilisi, T'bilisi, Georgia; 15Ivane Javakhishvili Tbilisi State University, International City, Dubai, United Arab Emirates; 16University cadi Ayyad, Marrakech, Marrakech-Tensift-Al Haouz, Morocco; 17Rhythm Heart and Critical Care, Nagpur, Nagpur, Maharashtra, India Introduction: Hepatocellular carcinoma and cirrhosis cause over 50,000 deaths annually in the U.S., with mortality rates revealing persistent and widening disparities by gender and race. Analyzing 20 years of CDC data, this study uncovers distinct mortality patterns driven by complex biological and social factors, underscoring an urgent need for targeted public health strategies to address these inequities and improve liver disease outcomes. Methods: We performed a retrospective analysis using the CDC WONDER database to examine adults aged ≥20 years who died from liver cancer or cirrhosis (ICD-10: C22, K70, K74) from 1999 to 2020. Annual age-adjusted mortality rates per 100,000 population were calculated and stratified by gender and race to characterize demographic disparities. Joinpoint regression was applied to identify statistically significant changes in mortality trends, with significance set at p < 0.05. Results: Female mortality rates were stable until 2009, then rose sharply by 4.13% annually, narrowing but not closing the gap with males, whose rates increased steadily by 2.79% per year and remained over twice as high by 2020 (4.63 vs. 2.06 per 100,000). Racial disparities were striking: American Indian/Alaska Native populations had the highest mortality in 2020 (5.01), rising 2.47% annually since 1999. Black mortality surged 4.57% annually from 2003 to 2013 before plateauing. Hispanic/Latino and White populations experienced steady increases after 2007 and 2003 (2.23% and 3.85% annually), reaching 4.77 and 3.31 per 100,000, respectively. Asian/Pacific Islanders had the lowest and most stable rates, rising modestly by 0.87% annually to 2.65. Discussion: Female mortality was stable until 2009, then rose 4.13% annually, narrowing but not closing the gap with males, whose rates grew 2.79% annually and remained over twice as high by 2020 (4.63 vs. 2.06 per 100,000). American Indian/Alaska Native mortality was highest in 2020 (5.01), rising 2.47% annually since 1999. Black rates surged 4.57% annually from 2003–2013 before plateauing. Hispanic/Latino and White mortality increased steadily (2.23% and 3.85% annually) to 4.77 and 3.31, while Asian/Pacific Islanders had the lowest, most stable rates, rising 0.87% to 2.65.
Figure: Trends in Age-Adjusted Mortality Rates for Cancer and Liver Fibrosis/Cirrhosis Stratified by Sex and Race/Ethnicity, United States (1999–2020)
Disclosures: Rakhshanda Khan indicated no relevant financial relationships. Harshawardhan Dhanraj Ramteke indicated no relevant financial relationships. Ashesh Das indicated no relevant financial relationships. Dineshbaba Murugavel indicated no relevant financial relationships. Sai Manohar Raju Obbani indicated no relevant financial relationships. Phanish Ravi indicated no relevant financial relationships. Anil Reddy Padi indicated no relevant financial relationships. Sri Mani Krishna Satvik Matta indicated no relevant financial relationships. Sonam Dhall indicated no relevant financial relationships. Vignesh Krishnadoss indicated no relevant financial relationships. Joshua Mohanan indicated no relevant financial relationships. Freny Lalchandani indicated no relevant financial relationships. Sneha Baiju indicated no relevant financial relationships. Joshua Annamalai indicated no relevant financial relationships. Achind Anil Kumar indicated no relevant financial relationships. Maryem Filal indicated no relevant financial relationships. Ivin Jolly indicated no relevant financial relationships. Manish Juneja indicated no relevant financial relationships.
Rakhshanda Khan, MBBS1, Harshawardhan Dhanraj Ramteke, MBBS2, Ashesh Das, MBBS3, Dineshbaba Murugavel, MD4, Sai Manohar Raju Obbani, MBBS5, Phanish Chandra. Ravi, MBBS6, Anil Reddy Padi, MBBS7, Sri Mani Krishna Satvik Matta, MBBS8, Sonam Dhall, MBBS9, Vignesh Krishnadoss, 10, Joshua Mohanan, 11, Freny Lalchandani, 12, Sneha Baiju, MBBS13, Joshua Annamalai, MD14, Achind Anil Kumar, MD15, Maryem Filal, MBBS16, Ivin Thomas. Jolly, MBBBS2, Manish Madanlal. Juneja, DM, MD, MBBS17. P1483 - Racial and Gender Disparities in Cancer and Liver Fibrosis/Cirrhosis Mortality Among US Adults: Insights From CDC WONDER (1999-2020), ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.
