P1143 - Gastrointestinal Cancer in Individuals With Inflammatory Bowel Disease: A Nationwide Study

Pojsakorn Danpanichkul, MD¹, Chalothorn Wannaphut, MD², Thanathip Suenghataiphorn, MD³, Noppachai Siranart, MD⁴, Sakditad Saowapa, MD¹, Vitchapong Prasitsumrit, MD¹
1Department of Internal Medicine, Texas Tech University Healt, Lubbock, TX; 2John A. Burns School of Medicine, University of Hawaii, Hawaii, HI; 3Griffin Hospital, Derby, CT; 4Brigham and Women's Hospital, Harvard Medical School, Boston, MA

Introduction: Patients with inflammatory bowel disease (IBD) face an increased risk of cancer-related mortality, encompassing both colorectal and other gastrointestinal malignancies; however, population-level data remain limited.

Methods: We analyzed death certificate data from the National Center for Health Statistics (2011–2020) to assess gastrointestinal cancer-related mortality among adults with IBD, calculating age-adjusted mortality rates (AAMRs) per 100,000 population and annual percent change (APC).

Results: : In 2020, a total of 4,261 individuals with IBD in the United States died from gastrointestinal cancer-related causes. Between 2011 and 2020, the AAMR for gastrointestinal cancer among IBD patients showed a significant upward trend, with an APC of 2.58% (95% CI: 0.34 to 4.87%). Males consistently exhibited higher AAMRs than females, and the rate of increase was more pronounced in males (APC: 2.15%, 95% CI: 0.38 to 3.96%), whereas rates among females remained stable. Among racial and ethnic groups, non-Hispanic Black individuals experienced the greatest rise in AAMR (APC: 4.16%, 95% CI: 1.28 to 7.13%). Regionally, the Northeast showed the highest increase in gastrointestinal cancer-related AAMR (APC: 2.24%, 95% CI: 0.74 to 3.75%).

Discussion: Gastrointestinal cancer-related mortality has increased among patients with IBD, with disproportionately higher rises observed in males, non-Hispanic Black individuals, and those residing in the Northeast census region


Figure: Table 1 Gastrointestinal cancer-related mortality in patients with inflammatory bowel disease

Disclosures:
Pojsakorn Danpanichkul indicated no relevant financial relationships.
Chalothorn Wannaphut indicated no relevant financial relationships.
Thanathip Suenghataiphorn indicated no relevant financial relationships.
Noppachai Siranart indicated no relevant financial relationships.
Sakditad Saowapa indicated no relevant financial relationships.
Vitchapong Prasitsumrit indicated no relevant financial relationships.

Pojsakorn Danpanichkul, MD¹, Chalothorn Wannaphut, MD², Thanathip Suenghataiphorn, MD³, Noppachai Siranart, MD⁴, Sakditad Saowapa, MD¹, Vitchapong Prasitsumrit, MD¹. P1143 - Gastrointestinal Cancer in Individuals With Inflammatory Bowel Disease: A Nationwide Study, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.