Skip to main content
ACG 2025 Annual Meeting Main banner
Icon Legend
This session is not in your Favorites.
This session is in your Favorites. Click again to remove it.
Presentation Icons
ACG Award Winner
ACG Award Winner
ACG Newsworthy Abstract
ACG Newsworthy Abstract
Registration Required
Registration Required
No CME
No CME
On-Demand Video
On-Demand Video
Livestream
Livestream

Sunday Poster Session

Category: Biliary/Pancreas

P0010 - Comparative One-Year Outcomes of Acute Kidney Injury and the Need for Hemodialysis in Patients With Acute Pancreatitis: Alcohol Users vs Non-Alcohol Users

Sunday, October 26, 2025
3:30 PM - 7:00 PM MT
Location: Exhibit Hall
Rashid Abdel-Razeq, MD1, Somtochukwu Onwuzo, MD2, Mohamad-Noor Abu-Hammour, MD3, Chidera Onwuzo, MBBS4, Lana Dardari, MD5, Barish Eren, MD1, Kojo-Frimpong B. Awuah, MD6, Antoine Boustany, MD7, Basil Jalamneh, MD1
1Cleveland Clinic Foundation, Cleveland, OH; 2Allegheny Center for Digestive Health, Pittsburgh, PA; 3Cleveland Clinic, Cleveland, OH; 4SUNY Upstate Medical University Hospital, Syracuse, NY; 5Cleveland Clinic Foundation, Westlake, OH; 6Allegheny Health Network, Pittsburgh, PA; 7Division of Gastroenterology, Department of Internal Medicine, University of Florida College of Medicine, Jacksonville, FL

Introduction: Acute pancreatitis (AP) can result in significant morbidity and mortality, particularly when associated with alcohol abuse. Acute kidney injury (AKI) and the need for hemodialysis are critical complications that can occur during the disease course. In this study, we aim to compare the one-year outcomes of acute pancreatitis among alcohol abusers vs non-alcohol abusers on the renal system.

Methods: We conducted a retrospective analysis of deidentified, aggregate patient data from TrinetX research network. The cohort comprised of patients 18 years old or older with diagnosis of acute pancreatitis. Patients were categorized into two cohorts: alcohol users and non-alcohol users. One-year outcomes including: AKI and the need for hemodialysis were compared between the two groups. Variables including age, gender, ethnicity, past medical history of diabetes mellitus, hypertension, metabolic syndrome, obesity, opioid and nicotine use known to cofound the association between the development of acute pancreatitis and composite outcomes. Thus, 1:1 propensity matching was used in this study. Cox proportional hazards regression analysis was also utilized to analyze the matched cohorts. Hazard ratios and 95% confidence intervals (95% CI) were reported in this analysis.

Results: The study included 72,771 patients in both the alcohol user and non-alcohol user groups after propensity score matching. Patients with acute pancreatitis who abused alcohol had a significantly higher incidence of acute kidney injury (AKI) compared to non-alcohol users (14.4% vs. 9.7%, OR=1.565, 95% CI: 1.516-1.616, p< 0.001). Conversely, the need for hemodialysis was lower in the alcohol-abusing cohort (0.048% vs. 0.100%, OR=0.479, 95% CI: 0.320-0.717, p< 0.001).

Discussion: Alcohol abuse in patients with acute pancreatitis was found to be associated with an increased risk of AKI. However, patients with alcohol-related acute pancreatitis had a lower likelihood of requiring hemodialysis compared to the other cohort. These findings highlight the importance of monitoring renal outcomes in patients with alcohol-related acute pancreatitis which may guide improvements in clinical management strategies.


Figure: Logarithmic comparison of AKI and hemodialysis incidence in alcohol vs. non-alcohol users with acute pancreatitis


Figure: Comparison of demographics and comorbidities of alcohol users and non-alcohol users before and after propensity score matching.

Disclosures:
Rashid Abdel-Razeq indicated no relevant financial relationships.
Somtochukwu Onwuzo indicated no relevant financial relationships.
Mohamad-Noor Abu-Hammour indicated no relevant financial relationships.
Chidera Onwuzo indicated no relevant financial relationships.
Lana Dardari indicated no relevant financial relationships.
Barish Eren indicated no relevant financial relationships.
Kojo-Frimpong B. Awuah indicated no relevant financial relationships.
Antoine Boustany indicated no relevant financial relationships.
Basil Jalamneh indicated no relevant financial relationships.

Rashid Abdel-Razeq, MD1, Somtochukwu Onwuzo, MD2, Mohamad-Noor Abu-Hammour, MD3, Chidera Onwuzo, MBBS4, Lana Dardari, MD5, Barish Eren, MD1, Kojo-Frimpong B. Awuah, MD6, Antoine Boustany, MD7, Basil Jalamneh, MD1. P0010 - Comparative One-Year Outcomes of Acute Kidney Injury and the Need for Hemodialysis in Patients With Acute Pancreatitis: Alcohol Users vs Non-Alcohol Users, ACG 2025 Annual Scientific Meeting Abstracts. Phoenix, AZ: American College of Gastroenterology.